Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lam, CSP; Lyass, A; Kraigher-Krainer, E; Massaro, JM; Lee, DS; Ho, JE; Levy, D; Redfield, MM; Pieske, BM; Benjamin, EJ; Vasan, RS.
Cardiac dysfunction and noncardiac dysfunction as precursors of heart failure with reduced and preserved ejection fraction in the community.
Circulation. 2011; 124(1):24-30
Doi: 10.1161/CIRCULATIONAHA.110.979203
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- Co-Autor*innen der Med Uni Graz
- Kraigher-Krainer Elisabeth
- Pieske Burkert Mathias
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- Abstract:
- Background-Heart failure (HF) is a clinical syndrome characterized by signs and symptoms involving multiple organ systems. Longitudinal data demonstrating that asymptomatic cardiac dysfunction precedes overt HF are scarce, and the contribution of noncardiac dysfunction to HF progression is unclear. We hypothesized that subclinical cardiac and noncardiac organ dysfunction would accelerate the manifestation of HF. Methods and Results-We studied 1038 participants of the Framingham Heart Study original cohort (mean age, 76 +/- 5 years; 39% men) with routine assessment of left ventricular systolic and diastolic function. Major noncardiac organ systems were assessed with the use of serum creatinine (renal), serum albumin (hepatic), ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1:FVC ratio; pulmonary), hemoglobin concentration (hematologic/oxygen-carrying capacity), and white blood cell count (systemic inflammation). On follow-up (mean, 11 years), there were 248 incident HF events (146 in women). After adjustment for established HF risk factors, antecedent left ventricular systolic dysfunction (hazard ratio, 2.33; 95% confidence interval, 1.43 to 3.78) and diastolic dysfunction (hazard ratio, 1.32; 95% confidence interval, 1.01 to 1.71) were associated with increased HF risk. After adjustment for cardiac dysfunction, higher serum creatinine, lower FEV1:FVC ratios, and lower hemoglobin concentrations were associated with increased HF risk (all P < 0.05); serum albumin and white blood cell count were not. Subclinical dysfunction in each noncardiac organ system was associated with a 30% increased risk of HF (P = 0.013). Conclusions-Antecedent cardiac dysfunction and noncardiac organ dysfunction are associated with increased incidence of HF, supporting the notion that HF is a progressive syndrome and underscoring the importance of noncardiac factors in its occurrence. (Circulation. 2011;124:24-30.)
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged, 80 and over -
- Creatinine - blood
- Diastole - physiology
- Female -
- Forced Expiratory Volume - physiology
- Heart - physiopathology
- Heart Failure - epidemiology Heart Failure - etiology Heart Failure - physiopathology
- Hemoglobins - metabolism
- Humans -
- Incidence -
- Kidney - metabolism Kidney - physiopathology
- Liver - metabolism Liver - physiopathology
- Longitudinal Studies -
- Lung - physiopathology
- Male -
- Oxidative Stress - physiology
- Risk Factors -
- Serum Albumin - metabolism
- Stroke Volume - physiology
- Systole - physiology
- Vital Capacity - physiology
- Find related publications in this database (Keywords)
- echocardiography
- epidemiology
- heart failure
- risk factors