Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Herndler-Brandstetter, D; Brunner, S; Weiskopf, D; van Rijn, R; Landgraf, K; Dejaco, C; Duftner, C; Schirmer, M; Kloss, F; Gassner, R; Lepperdinger, G; Grubeck-Loebenstein, B.
Post-thymic regulation of CD5 levels in human memory T cells is inversely associated with the strength of responsiveness to interleukin-15.
Hum Immunol. 2011; 72(8): 627-631.
Doi: 10.1016/j.humimm.2011.03.028
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- Co-Autor*innen der Med Uni Graz
- Dejaco Christian
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- Abstract:
- Immunologic memory is a critical feature of the adaptive immune system to fight recurrent infections. However, the mechanisms that shape the composition and function of the human memory T-cell pool remain incompletely understood. We here demonstrate that post-thymic human T-cell differentiation was associated with the downregulation, but not loss, of the inhibitory molecule CD5. The sensitivity of human CD8(+) and CD4(+) memory T cells to interleukin (IL)-15 was inversely associated with the level of CD5 expression. CD5 expression was downregulated by IL-15-mediated signaling in vitro and CD5(lo) memory T cells accumulated in the bone marrow. Persistent antigenic stimulation, as in the case of cytomegalovirus infection and rheumatoid arthritis (RA), was also associated with an increased number of CD5(lo) memory T cells. In conclusion, CD5 may be a useful marker to identify memory T-cell subsets with distinct responsiveness to the homeostatic cytokine IL-15. Copyright © 2011 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Antigens, CD5 - genetics
- Arthritis, Rheumatoid - immunology
- CD4-Positive T-Lymphocytes - cytology
- CD8-Positive T-Lymphocytes - cytology
- Cell Differentiation -
- Cells, Cultured -
- Cytomegalovirus - growth and development
- Cytomegalovirus Infections - immunology
- Enzyme-Linked Immunosorbent Assay -
- Flow Cytometry -
- Gene Expression - immunology
- Humans -
- Immunologic Memory -
- Interleukin-15 - genetics
- Signal Transduction - immunology
- T-Lymphocyte Subsets - cytology
- T-Lymphocytes - immunology
- Thymus Gland - cytology
- Find related publications in this database (Keywords)
- Human
- Memory T cell
- CD5
- Interleukin-15
- Bone marrow
- Rheumatoid arthritis