Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Schgoer, W; Mueller, T; Jauhiainen, M; Wehinger, A; Gander, R; Tancevski, I; Salzmann, K; Eller, P; Ritsch, A; Haltmayer, M; Ehnholm, C; Patsch, JR; Foeger, B.
Low phospholipid transfer protein (PLTP) is a risk factor for peripheral atherosclerosis.
Atherosclerosis. 2008; 196(1):219-226
Doi: 10.1016/j.atherosclerosis.2007.04.046
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Eller Philipp
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Objective: Phospholipid transfer protein (PLTP) facilitates cholesterol efflux from cells, intravascular HDL remodelling and transfer of vitamin E and endotoxin. In humans, the relationship of PUP to atherosclerosis is unknown. However, strong coronary risk factors like obesity, diabetes, cigarette smoking and inflammation increase circulating levels of active PUP. The aim of the present, cross-sectional study was to analyze the relationship of PLTP to peripheral arterial disease, a marker of generalized atherosclerosis, independently of potentially confounding factors like obesity, diabetes and smoking. Methods: We performed a case control study in 153 patients with symptomatic peripheral arterial disease (PAD) and 208 controls free of vascular disease. Smokers and patients with diabetes mellitus were excluded. A lipoprotein-independent assay was used for measurement of circulating bioactive PLTP and an ELISA utilizing a monoclonal antibody was used to analyze PLTP mass. Results: PUP activity was significantly decreased in patients with PAD 5.5 (4.6-6.4)(median (25th-75th percentile)) versus 5.9 (5.1-6.9) mu mol/mL/h in controls (p = 0.001). In contrast, PUP mass was similar in patients with PAD 8.5 mu g/mL (7.3-9.5) and in controls 8.3 mu g/mL (6.9-9.7) (p = 0.665). Multivariate logistic regression analysis revealed that PLTP activity is independently associated with the presence of PAD. PLTP activity was similar in patients with and without lipid-lowering drugs (p = 0.396). Conclusion: Our results show that in non-diabetic, non-smoking subjects low rather than high PLTP activity is a marker for the presence of peripheral arterial disease and that distribution of PUP between high-activity and low-activity forms may be compromised in atherosclerosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Atherosclerosis - metabolism
- Biological Markers - blood
- Case-Control Studies -
- Cross-Sectional Studies -
- Female -
- Humans -
- Male -
- Peripheral Vascular Diseases - metabolism
- Phospholipid Transfer Proteins - blood Phospholipid Transfer Proteins - metabolism
- Find related publications in this database (Keywords)
- phospholipid transfer protein (PLTP)
- peripheral arterial disease
- atherosclerosis
- high density lipoproteins (HDL)
- triglycerides