Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tancevski, I; Wehinger, A; Schgoer, W; Eller, P; Cuzzocrea, S; Foeger, B; Patsch, JR; Ritsch, A.
Aspirin regulates expression and function of scavenger receptor-BI in macrophages: studies in primary human macrophages and in mice.
FASEB J. 2006; 20(9):1328-1335
Doi: 10.1096/fj.05-5368com
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- Co-Autor*innen der Med Uni Graz
- Eller Philipp
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- Abstract:
- Scavenger receptor class B type I (SR-BI) has been shown to be expressed in human atherosclerotic plaque macrophages, where it is believed to reduce atherosclerosis by promoting cholesterol efflux. In this study we investigated the influence of aspirin and other NSAIDs on SR-BI expression and function in cultured human macrophages as well as in different mouse strains. Incubation of human macrophages with 0.5 mmol/l aspirin resulted in increased SR-BI protein expression and increased uptake of HDL-associated [3H]cholesteryl oleate without changes of SR-BI mRNA levels. In contrast, using 5 mmol/l of aspirin, SR-BI expression and function were significantly decreased. Sodium salicylate exerted similar effects on SR-BI expression, whereas no effects were observed using known COX1/2 inhibitors ibuprofen and naproxen, respectively. In in vivo studies low-dose aspirin treatment (6 mg/kg.day) induced SR-BI expression in wild-type and PPAR-alpha knockout mice, respectively, whereas the opposite effect was observed upon high-dose aspirin treatment (60 mg/kg.day) in these animals. We could show that COX-independent effects of aspirin were able to enhance expression of SR-BI in macrophages in a post-transcriptional, PPAR-alpha independent way, suggesting a novel pharmacologic effect of aspirin.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Aspirin - pharmacology
- Biological Transport -
- Cell Line -
- Cells, Cultured -
- Fluoresceins -
- Gene Expression Regulation - drug effects
- Humans -
- Lipoproteins, HDL - metabolism
- Macrophages - drug effects Macrophages - physiology
- Mice -
- Mice, Knockout -
- Monocytes - drug effects Monocytes - physiology
- PPAR alpha - deficiency PPAR alpha - genetics
- Prostaglandin-Endoperoxide Synthases - metabolism
- RNA, Messenger - genetics
- Scavenger Receptors, Class B - genetics Scavenger Receptors, Class B - metabolism
- Find related publications in this database (Keywords)
- SR-BI
- PPAR
- KO mice
- NF-kappa B