Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Eller, P; Schgoer, W; Mueller, T; Tancevski, I; Wehinger, A; Ulmer, H; Foeger, B; Haltmayer, M; Ritsch, A; Patsch, JR.
Hepatic lipase polymorphism and increased risk of peripheral arterial disease.
J Intern Med. 2005; 258(4):344-348
Doi: 10.1111/j.1365-2796.2005.01549.x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Eller Philipp
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Background. Hepatic lipase plays a key role in the metabolism of pro-atherogenic and anti-atherogenic lipoproteins affecting their plasma level as well as their physico-chemical properties. We hypothesized single nucleotide polymorphisms in the promoter region of the hepatic lipase gene to be associated with an increased risk for peripheral arterial disease (PAD). Methods. A total of 241 patients with PAD and 241 controls matched for sex and age (+/- 2 years) were genotyped cross-sectionally for the -250 single nucleotide polymorphism in the hepatic lipase promoter. Results. The frequency for the -250A allele in patients with PAD was 0.203, whereas it was 0.147 in the controls (P = 0.022). Hepatic lipase promoter polymorphism distribution remained significantly different between cases and controls after multivariate logistic regression analysis (P = 0.021). The odds ratio of the -250A hepatic lipase allele for the PAD was 1.69 (95% confidence interval of 1.08-2.64), when adjusted for current smoking, arterial hypertension, cholesterol, triglycerides, HbA(1C), total homocysteine and high sensitivity C-reactive protein. Conclusion. Previous data in patients with ischaemic heart disease have suggested a pro-atherogenic role of low hepatic lipase levels. Our results extend these data to the vascular territory of the lower limbs, such that hepatic lipase promoter variation represents a genetic risk factor of PAD.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Epidemiologic Methods -
- Female -
- Gene Frequency -
- Genetic Markers -
- Humans -
- Lipase - genetics
- Liver - enzymology
- Male -
- Middle Aged -
- Peripheral Vascular Diseases - enzymology Peripheral Vascular Diseases - genetics
- Polymerase Chain Reaction - methods
- Polymorphism, Single Nucleotide -
- Promoter Regions, Genetic -
- Find related publications in this database (Keywords)
- hepatic lipase
- peripheral arterial disease
- promoter polymorphism