Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Tancevski, I; Wehinger, A; Demetz, E; Hoefer, J; Eller, P; Huber, E; Stanzl, U; Duwensee, K; Auer, K; Schgoer, W; Kuhn, V; Fievet, C; Stellaard, F; Rudling, M; Foeger, B; Patsch, JR; Ritsch, A.
The thyromimetic T-0681 protects from atherosclerosis.
J Lipid Res. 2009; 50(5):938-944
Doi: 10.1194/jlr.M800553-JLR200
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- Co-Autor*innen der Med Uni Graz
- Eller Philipp
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- Abstract:
- This report describes studies in hyperlipidemic New Zealand White (NZW) rabbits investigating the impact of the liver-selective thyromimetic T-0681 on lipoprotein metabolism and the development of atherosclerosis. Prolonged treatment with T-0681 increased the hepatic expression of both LDL receptor and scavenger receptor class B, type I without affecting cholesteryl ester transfer protein activity. Upregulation of hepatic lipoprotein receptors was accompanied by a marked decrease of apolipoprotein B-containing lipoproteins, reflected by a 60% reduction of plasma cholesterol and a >70% reduction of plasma triglyceride levels. Most importantly, T-0681 reduced the development of atherosclerosis by 80% in NZW rabbits on high-cholesterol chow. Our data suggest that liver-selective thyromimetics, such as T-0681, may prove to be useful therapeutic agents against the development of atherosclerosis in humans.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anticholesteremic Agents - therapeutic use
- Antigens, CD36 - metabolism
- Aorta - anatomy and histology Aorta - pathology
- Atherosclerosis - prevention and control
- Cell Line -
- Cholesterol, Dietary -
- Diet -
- Disease Models, Animal -
- Humans -
- Hyperlipidemias - drug therapy
- Lipid Metabolism -
- Liver - metabolism
- Male -
- Malonates - therapeutic use
- Phenyl Ethers - therapeutic use
- Rabbits -
- Find related publications in this database (Keywords)
- liver-selective thyromimetic
- low density lipoprotein receptor
- scavenger receptor class B, type I
- potential side effects