Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Van Mieghem, T; Klaritsch, P; Done, E; Gucciardo, L; Lewi, P; Verhaeghe, J; Lewi, L; Deprest, J.
Assessment of fetal cardiac function before and after therapy for twin-to-twin transfusion syndrome
AMER J OBSTET GYNECOL. 2009; 200(4): 400.e1-400.e7.
Doi: 10.1016/j.ajog.2009.01.051
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Klaritsch Philipp
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- Abstract:
- OBJECTIVE: We sought to assess fetal cardiac function in monochorionic twins before and after therapy for twin-to-twin transfusion syndrome (TTTS) and compare it with control subjects. STUDY DESIGN: We conducted prospective longitudinal assessment of fetal cardiac function in cases undergoing curative fetal therapy for TTTS (n = 39) until 4 weeks postoperatively and in uncomplicated monochorionic twins (n = 23). Fetal cardiac function was assessed by the left and right ventricular myocardial performance index, atrioventricular valve flow pattern, ductus venosus a-wave, and umbilical vein pulsations. RESULTS: Nomograms for the myocardial performance index were constructed. Fetal cardiac function was grossly abnormal in recipient twins of TTTS when compared with control subjects (P < .001 for all indices) but normalized by 4 weeks postoperatively. The donor developed abnormal ductus venosus flow and tricuspid regurgitation postoperatively that regressed within 4 weeks. CONCLUSION: The cardiac dysfunction in the recipient twin of TTTS normalizes within 1 month after laser. The donor develops a transient impairment of cardiac function postoperatively.
- Find related publications in this database (using NLM MeSH Indexing)
- Female -
- Fetofetal Transfusion - physiopathology
- Fetus - surgery
- Gestational Age -
- Heart - physiopathology
- Heart Function Tests -
- Humans -
- Pregnancy -
- Prospective Studies -
- Find related publications in this database (Keywords)
- echocardiography
- fetoscopy
- laser coagulation
- monochorionic twins
- twin-to-twin transfusion syndrome