Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Klaritsch, P; Mayer, S; Sbragia, L; Toelen, J; Roubliova, X; Lewi, P; Deprest, JA.
Albumin as an adjunct to tracheal occlusion in fetal rats with congenital diaphragmatic hernia: a placebo-controlled study
AMER J OBSTET GYNECOL. 2010; 202(2): 198.e1-198198.
Doi: 10.1016/j.ajog.2009.10.877
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Klaritsch Philipp
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- Abstract:
- OBJECTIVE: We sought to investigate effects of intratracheal albumin injection prior to tracheal occlusion (TO) on lung proliferation in fetal rats with nitrofen-induced congenital diaphragmatic hernia. STUDY DESIGN: On embryonic day 19, nitrofen-exposed fetuses underwent TO, TO and 50 mu L of either intratracheal albumin 20% or saline, or remained untouched. Main outcome at embryonic day 21.5 was expression of the proliferation marker Ki-67. Secondary outcomes were lung-to-bodyweight ratio (LBWR), tropoelastin expression, density and spatial distribution of elastin, pulmonary/alveolar morphometry, and fetal survival. RESULTS: TO increased Ki-67 messenger RNA and LBWR. Albumin further increased LBWR and density of Ki-67-positive cells but also fetal mortality. TO with or without adjuncts induced elastin deposits at the tips of arising secondary crests, increased air space size, and decreased septal thickness. CONCLUSION: TO had effects on lung proliferation and advanced the morphologic appearance. Addition of albumin increased density of proliferating cells and LBWR, yet at the expense of additional fetal loss.
- Find related publications in this database (using NLM MeSH Indexing)
- Albumins - administration and dosage
- Animals -
- Cell Proliferation - drug effects
- Female -
- Fetal Diseases - physiopathology
- Fetal Organ Maturity - drug effects
- Hernia, Diaphragmatic - chemically induced
- Ki-67 Antigen - analysis
- Lung - embryology
- Pregnancy -
- Rats -
- Rats, Wistar -
- Trachea - surgery
- Find related publications in this database (Keywords)
- albumin
- diaphragmatic hernia
- fetal surgery
- pulmonary hypoplasia
- rat