Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Trauner, M; Baghdasaryan, A; Claudel, T; Fickert, P; Halilbasic, E; Moustafa, T; Zollner, G.
Targeting nuclear bile acid receptors for liver disease.
Dig Dis. 2011; 29(1):98-102 Doi: 10.1159/000324141
Web of Science PubMed FullText FullText_MUG

Führende Autor*innen der Med Uni Graz: Trauner Michael
Co-Autor*innen der Med Uni Graz: Baghdasaryan Anna; Claudel Thierry; Fickert Peter; Halilbasic Emina; Moustafa Tarek; Zollner Gernot
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Abstract:: Bile acids (BAs) are able to activate a range of dedicated nuclear receptors (NRs) which play a key role in the transcriptional control of critical steps of a wide range of hepatic functions ranging from BA homeostasis and bile formation, phase I/II metabolism of endo- and xenobiotics such as BAs and drugs, respectively, to hepatic lipids and glucose metabolism. Apart from these metabolic roles, BA-activated nuclear receptors also play a key role in the control of hepatic inflammation, fibrogenesis, replication of hepatitis B and C virus, liver regeneration and carcinogenesis. As such, several physiological and pathophysiological effects of BAs can now be explained through activation of regulatory NR networks. Moreover, BA-activated NRs are key for understanding the pathogenesis of several liver diseases and represent attractive drug targets. This article will provide a brief overview on the role of BA-activated NRs in cholestatic and fatty liver disease. Copyright © 2011 S. Karger AG, Basel.
Find related publications in this database (using NLM MeSH Indexing): Animals -; Bile Acids and Salts - metabolism; Cholestasis - metabolism; Homeostasis -; Humans -; Lipid Metabolism -; Liver Diseases - metabolism; Receptors, Cytoplasmic and Nuclear - metabolism
Find related publications in this database (Keywords): Bile acids; Nuclear receptors; Liver disease