Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Painsipp, E; Köfer, MJ; Sinner, F; Holzer, P.
Prolonged depression-like behavior caused by immune challenge: influence of mouse strain and social environment.
PLoS One. 2011; 6(6):e20719-e20719
Doi: 10.1371/journal.pone.0020719
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- Führende Autor*innen der Med Uni Graz
- Holzer Peter
- Singewald Evelin
- Co-Autor*innen der Med Uni Graz
- Köfer Martin Josef
- Sinner Frank Michael
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- Abstract:
- Immune challenge by bacterial lipopolysaccharide (LPS) causes short-term behavioral changes indicative of depression. The present study sought to explore whether LPS is able to induce long-term changes in depression-related behavior and whether such an effect depends on mouse strain and social context. LPS (0.83 mg/kg) or vehicle was administered intraperitoneally to female CD1 and C57BL/6 mice that were housed singly or in groups of 4. Depression-like behavior was assessed with the forced swim test (FST) 1 and 28 days post-treatment. Group-housed CD1 mice exhibited depression-like behavior 1 day post-LPS, an effect that leveled off during the subsequent 28 days, while the behavior of singly housed CD1 mice was little affected. In contrast, singly housed C57BL/6 mice responded to LPS with an increase in depression-like behavior that was maintained for 4 weeks post-treatment and confirmed by the sucrose preference test. Group-housed C57BL/6 mice likewise displayed an increased depression-like behavior 4 weeks post-treatment. The behavioral changes induced by LPS in C57BL/6 mice were associated with a particularly pronounced rise of interleukin-6 in blood plasma within 1 day post-treatment and with changes in the dynamics of the corticosterone response to the FST. The current data demonstrate that immune challenge with LPS is able to induce prolonged depression-like behavior, an effect that depends on genetic background (strain). The discovery of an experimental model of long-term depression-like behavior after acute immune challenge is of relevance to the analysis of the epigenetic and pathophysiologic mechanisms of immune system-related affective disorders.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Behavior, Animal - drug effects
- Body Weight - drug effects
- Body Weight - immunology
- Corticosterone - blood
- Depression - blood
- Depression - chemically induced
- Depression - immunology
- Depression - physiopathology
- Female -
- Food Preferences - drug effects
- Housing, Animal -
- Hypothalamo-Hypophyseal System - drug effects
- Hypothalamo-Hypophyseal System - immunology
- Hypothalamo-Hypophyseal System - physiopathology
- Interleukin-6 - blood
- Lipopolysaccharides - immunology
- Lipopolysaccharides - pharmacology
- Mice -
- Social Environment -
- Species Specificity -
- Sucrose -
- Time Factors -