Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wagner, M; Moore, DD.
Endoplasmic reticulum stress and glucose homeostasis.
Curr Opin Clin Nutr Metab Care. 2011; 14(4):367-373
Doi: 10.1097/MCO.0b013e32834778d4
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Wagner Martin
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- Abstract:
- Balancing glucose homeostasis is crucial to maintain appropriate energy and metabolic state. Chronic hyperglycemia with insulin resistance and development of type II diabetes mellitus is a growing health and health-economic threat. The unfolded protein response (UPR) is a mechanism by which the endoplasmic reticulum copes with diverse physiological and pathophysiological stress stimuli. Unresolved and chronic endoplasmic reticulum stress are important features in the development of diabetes mellitus. Understanding how the UPR impacts glucose balance and what disrupts this balance is critical for development of future therapies. In pancreatic β-cells, evidence is growing that the single branches of the UPR work in concert to supply insulin in response to acute glucose availability. Chronic glucose stimulation disrupts these primarily adaptive changes into an overwhelming UPR, which leads to reduced insulin supply and β-cell mass due to apoptosis. In hepatocytes, the UPR interacts with key transcription factors to physiologically regulate glucose and lipid homeostasis. Prolonged endoplasmic reticulum stress disrupts these feedback loops and results in ongoing gluconeogenesis and steatosis. Unraveling the molecular networks underlying the adaptive and contra-adaptive roles of the UPR in glucose metabolism will identify novel therapeutic approaches in the battle against diabetes mellitus.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Apoptosis -
- Diabetes Mellitus, Type 2 - metabolism
- Diabetes Mellitus, Type 2 - physiopathology
- Endoplasmic Reticulum - metabolism
- Glucose - metabolism
- Homeostasis -
- Humans -
- Insulin - metabolism
- Insulin Resistance -
- Insulin-Secreting Cells - metabolism
- Liver - metabolism
- Stress, Physiological -
- Unfolded Protein Response -
- Find related publications in this database (Keywords)
- diabetes
- insulin resistance
- nonalcoholic fatty liver disease
- transcription factors
- unfolded protein response