Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Zitt, E; Kirsch, AH; Haueis, M; Strasak, A; Neyer, U; Mayer, G; Rosenkranz, AR.
The PTH (1-84)/non-PTH (1-84) ratio is a risk factor for cardiovascular events in hemodialysis patients.
Clin Nephrol. 2011; 75(4):309-318
Doi: 10.5414/CNP75309
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- Führende Autor*innen der Med Uni Graz
- Rosenkranz Alexander
- Co-Autor*innen der Med Uni Graz
- Kirsch Alexander
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- Abstract:
- Background: We hypothesized that the PTH (1-84)/non-PTH (1-84) ratio (PTH ratio) might help to assess cardiovascular risk in hemodialysis patients. Methods: In this prospective cohort study 70 prevalent hemodialysis patients were followed up to 4 years. The PTH ratio was determined at base-line. Primary outcomes were cardiovascular events (CV E) and all-cause mortality. Cumulative event-free survival was compared between patients with a ratio < 1 and those with a ratio > 1. The risk-association of the PTH ratio with CVE was examined using an adjusted Multiple Cox Proportional Hazards model. Results: A PTH ratio > 1 was found in 34 patients (49%). During follow-up 26 patients suffered a CVE. Patients with a CVE showed a higher ratio than patients with event-free survival (p = 0.033). In patients with a ratio > 1 a significantly higher number of CVE occurred (53 vs. 22%; p = 0.013), and these patients showed a significantly shorter event-free survival (p = 0.032). In an adjusted Cox-proportional hazards model a higher PTH ratio was found to be independently associated with an elevated risk for CVE (HR = 3.2; 95% Cl 1.06 - 13.63; p = 0.04). Conclusions: A higher PTH (1-84)/non-PTH (1-84) ratio is associated with an increased risk for CVE in hemodialysis patients and might therefore be useful for cardiovascular risk estimation in this population.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Analysis of Variance -
- Biological Markers - blood
- Cardiovascular Diseases - blood
- Disease-Free Survival -
- Female -
- Humans -
- Kidney Failure, Chronic - blood
- Male -
- Middle Aged -
- Parathyroid Hormone - blood
- Proportional Hazards Models -
- Prospective Studies -
- Renal Dialysis -
- Risk Factors -
- Find related publications in this database (Keywords)
- PTH
- secondary hyperparathyroidism
- PTH (1-84)/non-PTH (1-84) ratio
- cardiovascular morbidity
- cardiovascular mortality
- hemodialysis