Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Youssef, RF; Shariat, SF; Lotan, Y; Cost, N; Wood, CG; Sagalowsky, AI; Zigeuner, R; Langner, C; Chromecki, TF; Montorsi, F; Bolenz, C; Margulis, V.
Urothelial carcinoma at the uretero-enteric junction: multi-center evaluation of oncologic outcomes after radical nephroureterectomy.
Urol Oncol. 2013; 31(5):676-681
Doi: 10.1016/j.urolonc.2011.05.006
Web of Science
PubMed
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- Co-authors Med Uni Graz
- Chromecki Thomas
- Langner Cord
- Zigeuner Richard
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- Abstract:
- Objective: The natural history of urothelial carcinoma arising at the uretero-enteric junction (UEJ) is poorly defined, and the data guiding clinical management of these patients is limited. Therefore, we evaluated oncologic outcomes of patients treated for urothelial carcinoma at the UEJ. Methods: Utilizing a multi-institutional database of patients treated with radical nephroureterectomy (RNU), we assessed the clinicopathologic parameters and oncologic outcomes of UEJ tumors compared with other upper tract urothelial carcinomas (UTUC). Survival analyses were performed to determine independent predictors of disease recurrence and cancer-specific mortality after RNU. Results: The study included 1,363 patients, 921 men and 442 women with 36 months median follow-up after RNU. Compared with UTUC in the kidney or ureter, UEJ tumors (n = 22) were more likely to demonstrate features of advanced disease, which were proved to be independent predictors of disease recurrence and cancer-specific mortality after RNU. The 5 year disease-free survival (DFS) and cancer-specific survival (CSS) rates were 25% and 39% in those with UEJ tumors vs. 69% and 73% in those with UTUC in the kidney or ureter (P = 0.001 and P = 0.008, respectively). Conclusions: UEJ tumors harbor features of locally advanced disease associated with high risk of systemic recurrence and death from cancer after RNU. Our findings suggest the need for integration of systemic therapy into the management paradigm of these patients. (C) 2013 Elsevier Inc. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Carcinoma, Transitional Cell - pathology
- Disease-Free Survival -
- Female -
- Follow-Up Studies -
- Humans -
- Kaplan-Meier Estimate -
- Male -
- Middle Aged -
- Multivariate Analysis -
- Neoplasm Recurrence, Local -
- Nephrectomy - methods
- Outcome Assessment (Health Care) - methods
- Proportional Hazards Models -
- Rectum - pathology
- Risk Factors -
- Time Factors -
- Ureter - pathology
- Urologic Neoplasms - pathology
- Find related publications in this database (Keywords)
- Urothelial carcinoma
- UEJ
- Prognosis