Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ropele, S; de Graaf, W; Khalil, M; Wattjes, MP; Langkammer, C; Rocca, MA; Rovira, A; Palace, J; Barkhof, F; Filippi, M; Fazekas, F.
MRI assessment of iron deposition in multiple sclerosis.
J Magn Reson Imaging. 2011; 34(1): 13-21.
Doi: 10.1002/jmri.22590
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- Führende Autor*innen der Med Uni Graz
- Ropele Stefan
- Co-Autor*innen der Med Uni Graz
- Fazekas Franz
- Khalil Michael
- Langkammer Christian
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- Abstract:
- Iron deposition in the human brain tissue occurs in the process of normal aging and in many neurodegenerative diseases. Elevated iron levels in certain brain regions are also an increasingly recognized finding in multiple sclerosis (MS). The exact mechanism(s) for this phenomenon and its implication in terms of pathophysiology and clinical significance are still largely unknown and debated. Reliable methods to exactly quantify brain iron are a first step to clarify these issues. Therefore, the aim of this review is to present currently available magnetic resonance imaging (MRI) techniques for the assessment of brain iron. These include relaxation time mapping, phase imaging, susceptibility-weighted imaging, susceptibility mapping, magnetic field correlation imaging, and direct saturation imaging. After discussing their advantages and disadvantages, existing MRI clinical correlations with brain iron concentration in MS are summarized and future research directions are shown.
- Find related publications in this database (using NLM MeSH Indexing)
- Brain - pathology
- Fourier Analysis -
- Humans -
- Iron - metabolism
- Macrophages - pathology
- Magnetic Resonance Imaging - methods
- Magnetics -
- Models, Biological -
- Multiple Sclerosis - metabolism
- Neurodegenerative Diseases - pathology
- Oxidative Stress -
- Time Factors -
- Find related publications in this database (Keywords)
- iron
- multiple sclerosis
- MRI
- relaxation time mapping
- magnetic susceptibility
- magnetic field correlation imaging