Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mann, K; Petek, E; Pertl, B.
Prenatal detection of chromosome aneuploidy by quantitative-fluorescence PCR.
Methods Mol Biol. 2011; 688:207-226
Doi: 10.1007/978-1-60761-947-5_14
PubMed
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- Co-authors Med Uni Graz
- Pertl Barbara
- Petek Erwin
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- Abstract:
- QF-PCR refers to the amplification of chromosome-specific polymorphic microsatellite markers using fluorescence-labelled primers, followed by semi-quantitative analysis of the products on a genetic analyser to determine copy number and/or imbalances of specific chromosomal material. This approach is now widely used for rapid prenatal diagnosis of the common trisomies. In addition, it can successfully detect maternal cell contamination and mosaicism in prenatal material.
- Find related publications in this database (using NLM MeSH Indexing)
- Amniotic Fluid - cytology
- Aneuploidy -
- Cell Line -
- Chorionic Villi - metabolism
- Chromosomes - genetics
- DNA - genetics DNA - isolation and purification
- Female -
- Genotype -
- Humans -
- Male -
- Polymerase Chain Reaction - methods
- Pregnancy -
- Prenatal Diagnosis - methods
- Spectrometry, Fluorescence - methods