Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Mangge, H; Almer, G; Zelzer, S; Vasan, R; Kraigher-Krainer, E; Gasser, R; Schnedl, W; Ille, R; Wallner, S; Möller, R; Horejsi, R; Weghuber, D.
N-terminal pro-B-type natriuretic peptide in early and advanced phases of obesity.
Clin Chem Lab Med. 2011; 49(9):1539-1545
Doi: 10.1515/CCLM.2011.627
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Mangge Harald
- Co-Autor*innen der Med Uni Graz
- Almer Gunter
- Gasser Robert
- Holasek Sandra Johanna
- Horejsi Renate
- Ille Rottraut
- Kraigher-Krainer Elisabeth
- Möller Reinhard
- Schnedl Wolfgang
- Zelzer Sieglinde
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- Abstract:
- Increased plasma amino-terminal-cleavage-fragment of NP (NT-proBNP) is an established indicator for heart failure. Moreover, obese adults had low circulating NT-proBNP suggesting an obesity-related dysregulation (natriuretic handicap). Secretion and/or clearance of NT-proBNP were discussed to be impaired in obesity. As only older adults were investigated so far, it remains unclear when during the evolution of obesity the state of a natriuretic handicap develops, and whether NT-proBNP may still serve as a relevant cardiac marker in obese juveniles. We analysed NT-proBNP in juvenile (n=274, 10-18 years) and middle-aged (n=277, 18-50 years) normal weight (n=213) and obese (n=338) probands together with complex anthropometry, carotis sonography, clinical, and laboratory parameters. NT-proBNP showed a significant gender and age interaction. Adult females had significant higher NT-proBNP than adult males, and higher levels than juvenile females. Adult males had lower levels than juvenile males. Only a weak age and weight interaction was seen with obese juveniles which showed higher NT-proBNP than obese adults. Moreover, normal weight probands had higher NT-proBNP than overweight and obese. In a multiple regression including all probands, gender, creatinine and uric acid were the best predictors for NT-proBNP. In adults, female gender is the strongest driver for increased NT-proBNP. These results argue against an essential influence of obesity to B-type cardiac natriuretic hormone system regulation in the absence of heart failure, and suggest NT-proBNP as a useful cardiac marker irrespective of age and obesity.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Body Weight -
- Child -
- Disease Progression -
- Family -
- Female -
- Humans -
- Male -
- Middle Aged -
- Natriuretic Peptide, Brain - blood
- Obesity - blood
- Obesity - pathology
- Obesity - physiopathology
- Peptide Fragments - blood
- Regression Analysis -
- Young Adult -
- Find related publications in this database (Keywords)
- natriuretic deficit
- NT-proBNP
- obese adults
- obese juveniles