Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Popper, H; Wrba, F; Gruber-Mösenbacher, U; Hulla, W; Pirker, R; Hilbe, W; Studnicka, M; Mohn-Staudner, A; Ploner, F; und die Arbeitsgruppe Pulmopathologie der ÖGP-IAP.
Histology-based algorithm in the molecular diagnosis of mutations of the Epidernal Growth Factor Receptor (EGFR) in non-small cell lung cancer.
Wien Klin Wochenschr. 2011; 123(9-10):316-321
Doi: 10.1007/s00508-011-1573-8
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PubMed
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- Führende Autor*innen der Med Uni Graz
- Popper Helmuth
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- Abstract:
- Patients with stage IIIB and IV non-small cell lung carcinoma (NSCLC) harboring an activating mutation of the Epidermal Growth Factor Receptor (EGFR) Gene should be treated first-line with Gefitinib, an EGFR tyrosine kinase inhibitor (TKI). EGF receptor mutations are most common in adenocarcinomas, especially non-mucinous type, rare in squamous cell carcinomas and sarcomatoid carcinomas, and do not occur in neuroendocrine carcinomas. Therefore, the Pulmonary Pathology Working Group of the Austrian Society of Pathology, after intense discussions and in consensus with Oncologists and Pulmonologists, recommends a priori EGFR mutation analysis for all cases of adenocarcinoma, and for all other NSCLC upon clinical request. This will markedly reduce waiting time for those patients, which most likely will have the greatest benefit from EGFR TKI therapy.
- Find related publications in this database (using NLM MeSH Indexing)
- Adenocarcinoma - drug therapy
- Algorithms -
- Algorithms -
- Carcinoma, Non-Small-Cell Lung - drug therapy
- DNA Mutational Analysis -
- Drug Delivery Systems -
- Humans -
- Lung - pathology
- Lung Neoplasms - drug therapy
- Neoplasm Staging -
- Protein Kinase Inhibitors - therapeutic use
- Quinazolines - therapeutic use
- Receptor, Epidermal Growth Factor - genetics
- Find related publications in this database (Keywords)
- Non-small cell lung cancer
- EGFR activating mutations
- adenocarcinoma
- targeted therapy