Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
von Bueren, AO; von Hoff, K; Pietsch, T; Gerber, NU; Warmuth-Metz, M; Deinlein, F; Zwiener, I; Faldum, A; Fleischhack, G; Benesch, M; Krauss, J; Kuehl, J; Kortmann, RD; Rutkowski, S.
Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology.
Neuro Oncol. 2011; 13(6):669-679
Doi: 10.1093/neuonc/nor025
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- Co-Autor*innen der Med Uni Graz
- Benesch Martin
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- Abstract:
- This study was designed to confirm the previously observed favorable survival rates and prognostic factors in young children with nonmetastatic medulloblastoma (MB) treated with postoperative chemotherapy alone. Patients who received a diagnosis during the period January 2001 through December 2005 and who were aged <4 years received 3 cycles of postoperative systemic multiagent chemotherapy and intraventricular methotrexate. In cases of complete remission, treatment was terminated after 2 additional cycles of chemotherapy. Otherwise, secondary surgery, radiotherapy, and consolidation chemotherapy were recommended. At a median follow-up of 4.5 years, the 5-year event-free survival (EFS) and overall survival (OS) rates (± standard error) for 45 patients (median age, 2.5 years) were 57% ± 8% and 80% ± 6%, respectively. Nineteen patients with desmoplastic/nodular MB variants had better 5-year EFS and OS rates (90% ± 7% and 100% ± 0%, respectively) than did 23 patients with classic MB (30% ± 11% and 68% ± 10%, respectively; P < .001 for EFS; P = .008 for OS). Five-year EFS and OS rates for 3 children with anaplastic MB were 33% ± 27%. Desmoplastic/nodular histology was an independent prognostic factor for EFS. Twenty-nine of 30 patients without postoperative residual tumor remained in continuous complete remission. Our results confirm that histology of MB variants is a strong prognostic factor in this age group. Sustained tumor control can be achieved by this chemotherapy regimen in young children with desmoplastic/nodular MB variants. For children with non-desmoplastic/nonnodular MB variants, for which predominantly local relapses lead to less favorable survival rates, local radiotherapy has been introduced after chemotherapy since 2006.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Combined Chemotherapy Protocols - therapeutic use
- Carboplatin - administration & dosage
- Cerebellar Neoplasms - pathology
- Child, Preschool -
- Combined Modality Therapy -
- Cyclophosphamide - administration & dosage
- Etoposide - administration & dosage
- Female -
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- Humans -
- Infant -
- Leucovorin - administration & dosage
- Magnetic Resonance Imaging -
- Male -
- Medulloblastoma - pathology
- Methotrexate - administration & dosage
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- Find related publications in this database (Keywords)
- brain tumor
- chemotherapy
- children
- medulloblastoma
- treatment