Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Gantner, S; Wiesner, T; Cerroni, L; Lurkin, I; Zwarthoff, EC; Landthaler, M; Hafner, C.
Absence of BRAF and HRAS mutations in eruptive Spitz naevi
BRIT J DERMATOL. 2011; 164(4): 873-877.
Doi: 10.1111/j.1365-2133.2011.10210.x
(- Case Report)
Web of Science
PubMed
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FullText_MUG
- Co-Autor*innen der Med Uni Graz
- Cerroni Lorenzo
- Wiesner Thomas
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- Abstract:
- Eruptive Spitz naevi have been reported rarely in the literature. In solitary Spitz naevi, BRAF and HRAS mutations, as well as increased copy numbers of chromosome 11p have been identified. To investigate the genetic changes underlying eruptive Spitz naevi. We report on a 16-year-old boy who developed multiple disseminated eruptive Spitz naevi within a few months. We analysed BRAF, HRAS, KRAS and NRAS genes in 39 naevi from this patient for hotspot mutations. Furthermore, comparative genomic hybridization analysis was performed in three lesions. None of the Spitz naevi displayed a mutation in the analysed genes, and no chromosomal imbalances were observed. Conclusions Our results indicate that the typical genetic alterations described in solitary Spitz naevi appear to be absent in eruptive Spitz naevi. Yet unknown alternative genetic alterations must account for this rare syndrome. © 2011 The Authors. BJD © 2011 British Association of Dermatologists.
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