Medizinische Universität Graz - Research portal
Selected Publication:
Skrabal, F; Kotanko, P; Wach, P; Kenner, T; Lueger, A; Raid, H; Rieger, E.
Further advances in the salt sensitivity hypothesis in man
KLIN WOCHENSCHR. 1991; 69 Suppl 25(2): 36-40.
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- Co-authors Med Uni Graz
- Kenner Thomas
- Lueger Andreas
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- Abstract:
- The hypothesis, proposed by us since 1981, that genetically determined salt sensitivity exists in the normotensive population has been confirmed by other groups. We propose that in salt sensitive subjects an augmented upregulation of alpha-2 combined with simultaneous downregulation of beta-2 adrenoceptors by a high salt diet (resulting in an increase in the "operative" adrenoceptor ratio) is responsible for the rise of blood pressure. In salt resistant subjects the "operative alpha-2/beta-2 adrenoceptor ratio" does not increase on a high salt intake. The adrenoceptor changes in salt sensitive subjects probably lead to an increased central sympathetic outflow (through receptor changes in certain brain areas) and to simultaneous enhanced end-organ response in resistance vessels and in the kidney, causing enhanced vasoconstriction and enhanced sodium reabsorption. Long term follow up of salt sensitive normotensives will show, whether they develop "essential hypertension" in the future.
- Find related publications in this database (using NLM MeSH Indexing)
- Absorption -
- Blood Pressure - drug effects
- Disease Susceptibility - drug effects
- Humans - drug effects
- Receptors, Adrenergic - drug effects
- Sodium - metabolism
- Sodium, Dietary - adverse effects
- Vasoconstriction - drug effects
- Find related publications in this database (Keywords)
- Salt Sensitivity
- Adrenoceptor Regulation
- Essential Hypertension
- Central Sympathetic Outflow