Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Kenner, L; Beham-Schmid, C; Kerbl, R; Schmidt, HH; Sill, H; Hoefler, G.
ABL amplification in a patient with lymphoid blast crisis of chronic myelogenous leukaemia.
Virchows Arch. 1999; 434(3):255-257
Doi: 10.1007%2Fs004280050337
(- Case Report)
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- Führende Autor*innen der Med Uni Graz
- Höfler Gerald
- Kenner Lukas
- Co-Autor*innen der Med Uni Graz
- Beham-Schmid Christine
- Kerbl Reinhold
- Schmidt Helmut
- Sill Heinz
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- Abstract:
- Although chronic phase myelogenous leukaemia (CML) is characterised by the Philadelphia (Ph) chromosome leading to a fusion of the BCR and ABL genes, additional genetic alterations involved in blast crisis are poorly understood. We report an at least 15-fold amplification of the ABL oncogene in a 29-year-old male patient with a variant Ph-positive t(19;22)(p13;q11.2) CML who presented in lymphoid blast crisis. Our finding suggests that an amplification of the ABL oncogene might play a part in the appearance of an aggressive phenotype in some cases of CML.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Blast Crisis - pathology
- Blotting, Southern - pathology
- Chronic Disease - pathology
- Gene Amplification - pathology
- Genes, abl - genetics
- Humans - genetics
- Leukemia, Myeloid, Philadelphia-Positive - genetics
- Lymphocytes - pathology
- Male - pathology
- Find related publications in this database (Keywords)
- BCR-ABL
- Amplification
- CML
- Blast Crisis