Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Pakisch, B; Obermayerpietsch, B; Mokry, M; Poier, E; Warnkross, H; Clarici, G; Leb, G; Stucklschweiger, G; Hackl, A.
Function of the Anterior-Pituitary Gland Following Surgical and Radiotherapeutic Management for Pituitary-Adenoma
TUMORDIAGN THER. 1992; 13: 60-65.
Web of Science
- Co-Autor*innen der Med Uni Graz
- Hackl Arnulf
- Mokry Michael
- Obermayer-Pietsch Barbara
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- Abstract:
- Fifty-five adult patients with adenoma of the pituitary gland (20/55 with hyperfunctional tumors, 21/55 with endocrine inactive tumors, and 14/55 with hormonal deficits at the time of diagnosis) were studied retrospectively in terms of their endocrine outcome after surgery and radiotherapy. Twenty-two percent of the patients developed new hormone deficiency after surgery and 33% after radiotherapy. After a median follow-up time of 4.6 years, 44/53 patients had a pituitary dysfunction and 35/44 a gonadotropin deficiency. There seems to be a correlation between the daily single dose given and the development of endocrine dysfunction, as 15/35 (43%) of those patients who received 2.0 Gy per day developed hormonal deficiencies, compared to 6/20 (30%) of those who received 1.8 Gy per day. The median time from radiotherapy to onset of endocrine abnormalities was 19,7 months. Normalization of the prolactin levels occurred in 55% of the cases, and that of hGH levels in 80%. An ongoing hormone replacement was necessary in 69% of the patients.
- Find related publications in this database (Keywords)
- Pituitary Adenoma
- Prolactinoma
- Acromegaly
- Pituitary Irradiation
- Pituitary Surgery
- Hypopituitarism