Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Graupp, M; Wehr, E; Schweighofer, N; Pieber, TR; Obermayer-Pietsch, B.
Association of genetic variants in the two isoforms of 5α-reductase, SRD5A1 and SRD5A2, in lean patients with polycystic ovary syndrome.
Eur J Obstet Gynecol Reprod Biol. 2011; 157(2):175-179
Doi: 10.1016/j.ejogrb.2011.03.026
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- Führende Autor*innen der Med Uni Graz
- Koiner-Graupp Matthias
- Co-Autor*innen der Med Uni Graz
- Lerchbaum Elisabeth
- Obermayer-Pietsch Barbara
- Pieber Thomas
- Schweighofer Natascha
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- Abstract:
- Objective: Given its role in converting testosterone to dihydrotestosterone and cortisol to dihydrocortisol, 5 alpha-reductase may be important in the pathophysiology of the polycystic ovary syndrome (PCOS). Increased activity of this enzyme has already been demonstrated in ovaries of affected women, and might be caused by genetic alterations. The aim of this study was to analyze representative genetic variants of both isoforms of 5 alpha-reductase with regard to PCOS parameters in lean and obese women. Study design: We analyzed one single nucleotide polymorphism (SNP) (rs523349) of the isoform 2 (SRD5A2) and one haplotype of the isoform 1 (SRD5A1), consisting of the two SNPs rs39848 and rs3797179, in 249 women with PCOS and 226 healthy women using a 5'-exonuclease-assay. The genotypes were associated with anthropometric, metabolic and hormonal as well as functional tests in these women. Results: In the investigated haplotype of SRD5A1, the TA variant was associated with an increased frequency of PCOS (P=0.022) and an increased Ferriman-Gallwey Score (hirsutism) (P= 0.016) in women with normal weight. The G allele at the examined position of the SRD5A2 showed a decreased frequency of PCOS (P= 0.03) in women with normal weight. Conclusion: One of the keys in the development of the PCOS is hyperandrogenism, which might be caused by an increased 5 alpha-reductase activity, as it is often seen in obesity. This mechanism might therefore be of importance in lean PCOS patients and contribute to the clinical findings. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- 3-Oxo-5-alpha-Steroid 4-Dehydrogenase - genetics
- Adult -
- Body Weight - genetics
- Case-Control Studies -
- Cholestenone 5 alpha-Reductase - genetics
- Female -
- Genotype -
- Haplotypes - genetics
- Humans -
- Isoenzymes - genetics
- Membrane Proteins - genetics
- Obesity - epidemiology
- Polycystic Ovary Syndrome - epidemiology
- Polymorphism, Single Nucleotide - genetics
- Prevalence -
- Thinness - epidemiology
- Find related publications in this database (Keywords)
- Polycystic ovary syndrome
- 5 alpha-Reductase
- Polymorphisms
- Hyperandrogenemia