Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Porta, S; Walzl, M; Kisters, K; Korisek, G; Pichlkastner, K; Gell, H; Porta, J.
The role of ionized magnesium in metabolic changes during 54 hours of exhaustive sleep deprivation - a case report
TRACE ELEM ELECTROLYTES. 2011; 28(2): 83-87.
Doi: 10.5414/TEP213083
Web of Science
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- Führende Autor*innen der Med Uni Graz
- Porta Sepp
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- Abstract:
- From a male proband of similar to 35 y, 1.77 m height and 75 kg and excellent fitness who agreed to keep himself awake for at least 52 h, 100 mu l of capillary blood was sampled repeatedly for determination of Mg, pH, pO(2), pCO(2), lactate and blood glucose. Drowsiness was determined by pupillometry, self adjudgement of state of well-being by a visual analogue scale. Sampling times (in terms of sleepless hours) were: after 14, 21, 26, 39, 41, 45, 51 h. Blood glucose increased, peaking at 180 mg/dl at 28 h. The consecutive fall (along with sharp increase in lactate) is attributed to both increased gluconeogenesis and anaerobic glycolysis. The timing of this peak could be a marker for individual fitness. Magnesium is lost from the blood in considerable amounts. This magnesium loss is the only parameter measured which correlates with indicators of both acute (pH, pCO(2)) and chronic (VAS) effects, thus underlining its overall need and thereby the urgent necessity of its supplementation in threatening exhaustion. bolic reactions to such a prolonged exhaustive sleep deprivation is rare.
- Find related publications in this database (Keywords)
- sleep deprivation
- exhaustion
- hyperglycemia
- correlative magnesium depletion