Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Edelmann, F; Stahrenberg, R; Polzin, F; Kockskamper, A; Dungen, HD; Duvinage, A; Binder, L; Kunde, J; Scherer, M; Gelbrich, G; Hasenfuss, G; Pieske, B; Wachter, R; Herrmann-Lingen, C.
Impaired physical quality of life in patients with diastolic dysfunction associates more strongly with neurohumoral activation than with echocardiographic parameters: Quality of life in diastolic dysfunction
AMER HEART J. 2011; 161(4): 797-804.
Doi: 10.1016/j.ahj.2011.01.003
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Kockskämper Anke
- Pieske Burkert Mathias
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- Abstract:
- Background Quality of life (QoL) is impaired in diastolic heart failure. Little is known about QoL in diastolic dysfunction (DD) without heart failure. Methods In the DIAST-CHF observational study, outpatients with risk factors for or a history of heart failure were included. In a cross-sectional analysis, we classified patients with preserved systolic function as having normal diastolic function (N, n = 264) or DD without (DD-, n = 957) or with (DD+, n = 321) elevated filling pressures according to echocardiography. Quality of life was evaluated by the Short Form 36 (SF-36) questionnaire. Results Short Form 36 physical function (SF-36-PF) was worse in DD+ (mean +/- SD 67.2 +/- 25.6) than in DD- (76.2 +/- 22.7, P < .05) than in N (mean +/- SD 81.1 +/- 23.5, P < .01). Other physical dimensions and the physical component score were also lower in DD, whereas the mental component score did not differ. The SF-36-PF correlated weakly with echocardiographic indicators of diastolic function. In multivariate linear regression controlling for age, sex, body mass index, depressiveness as assessed by Patient Health Questionnaire 9, N-terminal probrain-type natriuretic peptide, and midregional proadrenomedullin (MR-proADM), individual echocardiographic parameters or grade of DD was not independently associated with SF-36-PF, whereas the presence of DD+ was. Both N-terminal probrain-type natriuretic peptide and MR-proADM were independently associated with SF-36-PF, with MR-proADM showing the stronger association. Conclusions Physical dimensions of QoL are reduced in DD. Impaired SF-36-PF is only weakly associated with DD per se but rather seems to be contingent on the presence of elevated filling pressures. Biomarkers are more strongly and independently associated with SF-36-PF and may be more adequate surrogate markers of QoL in DD than echocardiographic measurements. (Am Heart J 2011; 161: 797-804.)
- Find related publications in this database (using NLM MeSH Indexing)
- Adrenomedullin - blood
- Aged -
- Aged, 80 and over -
- Biological Markers - blood
- Cross-Sectional Studies -
- Echocardiography -
- Female -
- Heart Failure, Diastolic - blood Heart Failure, Diastolic - physiopathology Heart Failure, Diastolic - ultrasonography
- Humans -
- Male -
- Middle Aged -
- Natriuretic Peptide, Brain - blood
- Protein Precursors - blood
- Quality of Life -
- Risk Factors -
- Ventricular Dysfunction, Left - blood Ventricular Dysfunction, Left - physiopathology Ventricular Dysfunction, Left - ultrasonography