Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Bernecker, C; Ragginer, C; Fauler, G; Horejsi, R; Möller, R; Zelzer, S; Lechner, A; Wallner-Blazek, M; Weiss, S; Fazekas, F; Bahadori, B; Truschnig-Wilders, M; Gruber, HJ.
Oxidative stress is associated with migraine and migraine-related metabolic risk in females.
Eur J Neurol. 2011; 18(10):1233-1239
Doi: 10.1111/j.1468-1331.2011.03414.x
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Bernecker Claudia
- Co-Autor*innen der Med Uni Graz
- Fauler Günter
- Fazekas Franz
- Gruber Hans-Jürgen
- Horejsi Renate
- Lechner Anita
- Möller Reinhard
- Ragginer Christine
- Truschnig-Wilders Martini
- Wallner-Blazek Mirja
- Zelzer Sieglinde
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- Abstract:
- Background and purpose: Oxidative stress is discussed to be implicated in the pathophysiology of migraine. However, data are in part controversial and the possible underlying mechanisms remain elusive to date. The aim of this study was to investigate the oxidative stress status of female patients with migraine and its implications on migraine-related metabolic alterations. Methods: Oxidative stress markers malondialdehyde (MDA), 4-hydroxy-2-nonenal (HNE), carbonylated proteins, parameters of associated nitric oxide stress, inflammation, lipid-and glucose-metabolism were determined in the interictal phase in female patients with migraine and controls. Results: We found significantly increased HNE levels in female migraineurs compared with controls. Logistic regression analyses of HNE revealed an odds ratio for migraine of 4.55. HNE showed significant correlations with the nitric oxide pathway, the insulin-and the lipid-metabolism. Conclusions: We show here that increased oxidative stress is associated with migraine and contributes to migraine-related metabolic risk like nitrosative stress, an atherogenic lipid profile and hyperinsulinemia. Our data suggest that oxidative stress may represent a key event in the pathophysiology of migraine and a suitable therapeutic target.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Cohort Studies -
- Female -
- Humans -
- Inflammation - epidemiology
- Lipid Metabolism - physiology
- Middle Aged -
- Migraine Disorders - epidemiology
- Oxidative Stress - physiology
- Risk Factors -
- Sex Characteristics -
- Find related publications in this database (Keywords)
- 4-hydroxy-2-nonenal
- malondialdehyde
- migraine
- oxidative stress