Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Zelzer, S; Fuchs, N; Almer, G; Raggam, RB; Prüller, F; Truschnig-Wilders, M; Schnedl, W; Horejsi, R; Möller, R; Weghuber, D; Ille, R; Mangge, H.
High density lipoprotein cholesterol level is a robust predictor of lipid peroxidation irrespective of gender, age, obesity, and inflammatory or metabolic biomarkers.
Clin Chim Acta. 2011; 412(15-16):1345-1349
Doi: 10.1016/j.cca.2011.03.031
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Mangge Harald
- Zelzer Sieglinde
- Co-authors Med Uni Graz
- Almer Gunter
- Horejsi Renate
- Ille Rottraut
- Möller Reinhard
- Prüller Florian
- Raggam Reinhard Bernd
- Schnedl Wolfgang
- Truschnig-Wilders Martini
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- Abstract:
- Obesity related dyslipidemia, chronic inflammation and oxidative stress were associated with atherosclerotic sequels. We analysed oxidized low-density lipoprotein (oxLDL) plasma levels of 797 participants of the STyrian Juvenile OBesity (STYJOBS) / Early DEteCTion of Atherosclerosis (EDECTA) Study cohort aged from 5 to 50 years. The rationale of STYJOBS/EDECTA is to investigate the preclinical phase of obesity by a well defined cohort of young and middle aged overweight/obese and normal weight subjects. Plasma oxLDL was analysed by ELISA (Mercodia, Sweden). In the overweight/obese (OW/OB) study group, oxLDL levels were significantly increased compared to normal weighted controls (p<0.001). Probands with metabolic syndrome (MS) had significantly higher oxLDL levels than probands without MS; between overweight and obese participants, and between females and males, no significant difference was seen. In a multiple stepwise regression analysis including all study subjects, age, gender, anthropometric data, presence of metabolic syndrome, systolic, diastolic blood pressure, carotis communis intima media thickness, lipids, adipokines, metabolic, and inflammatory biomarkers, decreased high-density lipoprotein (HDL-cholesterol) and increased total cholesterol were the best predictors for increased oxLDL levels. Decreased HDL-cholesterol is an important determinant of lipid peroxidation irrespective of obesity, age, gender, SAT distribution, and inflammatory/metabolic biomarkers. Copyright © 2011 Elsevier B.V. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Age Factors -
- Biomarkers - blood
- Biomarkers - metabolism
- Child -
- Child, Preschool -
- Cholesterol, HDL - blood
- Cholesterol, HDL - metabolism
- Cohort Studies -
- Female -
- Humans -
- Inflammation - blood
- Lipid Peroxidation -
- Male -
- Metabolic Syndrome - blood
- Middle Aged -
- Obesity -
- Predictive Value of Tests -
- Prospective Studies -
- Sex Factors -
- Young Adult -
- Find related publications in this database (Keywords)
- Oxidized LDL
- Obesity
- HDL-cholesterol