Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Hofmann, G; Langsenlehner, U; Langsenlehner, T; Glehr, M; Gerger, A; Absenger, G; Szkandera, J; Fuerst, F; Samonigg, H; Krippl, P; Renner, W.
Single nucleotide polymorphisms of integrin alpha-2 and beta-3 genes are not associated with relapse-free and overall survival in colorectal cancer patients.
Anticancer Res. 2011; 31(4):1373-1377
Web of Science
PubMed
- Führende Autor*innen der Med Uni Graz
- Hofmann Guenter
- Co-Autor*innen der Med Uni Graz
- Absenger Gudrun
- Gerger Armin
- Glehr Mathias
- Krippl Peter
- Langsenlehner Tanja
- Langsenlehner Uwe
- Moazedi-Fürst Florentine
- Renner Wilfried
- Samonigg Hellmut
- Szkandera Joanna
- Altmetrics:
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- Abstract:
- Background: Integrins influence tumourigenesis, tumor progression and development of metastases. The impact of polymorphisms in integrin genes on relapse-free survival (RFS) and overall survival (OS) for 433 Caucasian patients with colorectal cancer was analysed in this retrospective study. Patients and Methods: A Cox regression model including integrin genotype, age, grading, tumour size, number of lymph nodes examined, number of metastatic lymph nodes, stage and application of fluorouracil-based adjuvant chemotherapy was used to estimate their effect. Results: After a median follow-up of 41 months for RFS and 55 months for OS, no significant correlation between the ITGA2 1648A allele (RFS p=0.618, OS p=0.604), the ITGA2 807T allele (RFS p=0.603, OS p=0.807) and the ITGB3 176C allele (RFS p=0.719, OS p=0.261) and survival was detectable. Conclusion: The investigated integrin polymorphisms are not associated with RFS or OS in colorectal cancer patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Antimetabolites, Antineoplastic - therapeutic use
- Chemotherapy, Adjuvant -
- Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality
- DNA, Neoplasm - genetics
- Female -
- Fluorouracil - therapeutic use
- Follow-Up Studies -
- Humans -
- Integrin alpha2 - genetics
- Integrin beta3 - genetics
- Male -
- Middle Aged -
- Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - mortality
- Polymerase Chain Reaction -
- Polymorphism, Single Nucleotide - genetics
- Prognosis -
- Retrospective Studies -
- Survival Rate -
- Find related publications in this database (Keywords)
- Integrins
- colorectal cancer
- survival
- polymorphisms
- single nucleotide polymorphisms