Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Raju, R; Devi, SK; Mehervani, C; Kumar, AS; Meena, AK; Reddy, PP; Pranay, P; Jain, S; Archelos-Gracia, JJ; Suneetha, S; Suneetha, LM.
Antibodies to myelin P0 and ceramide perpetuate neuropathy in long standing treated leprosy patients.
Neurochem Res. 2011; 36(5):766-773
Doi: 10.1007/s11064-010-0397-7
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Archelos-Garcia Juan-Jose
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- Abstract:
- Anti neural antibodies are known to play a role in the immunopathogenesis of nerve damage in leprosy and HIV/AIDS. Myelin Protein zero (P0) and ceramide are two nerve components which maintain the integrity of the peripheral nerve. The present study was undertaken to identify antibodies to myelin P0 and ceramide in the sera of treated leprosy patients, HIV positive individuals and healthy subjects using enzyme linked immunosorbant assay (ELISA). The results revealed that treated leprosy patients continue to have significantly elevated myelin P0 and ceramide antibody levels as compared to healthy subjects (P < 0.05). The elevated antibody response to myelin P0 and ceramide in leprosy patients indicate a low grade autoimmune activity that perpetuates nerve damage in treated leprosy. There was no significant difference in the myelin P0 and ceramide antibody levels between HIV positive and healthy subjects (P > 0.05) suggesting that these antibodies do not play a role in early HIV infection.
- Find related publications in this database (using NLM MeSH Indexing)
- Autoantibodies - immunology
- Case-Control Studies -
- Ceramides - immunology
- Enzyme-Linked Immunosorbent Assay -
- HIV Infections - complications
- Humans -
- Immunohistochemistry -
- Leprosy - complications
- Myelin P0 Protein - immunology
- Peripheral Nervous System Diseases - complications
- Find related publications in this database (Keywords)
- Leprosy
- HIV/AIDS
- Myelin P0
- Ceramide
- Neuropathy