Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Lackner, C; Offner, F; Nizze, H.
Small intestine, pancreas and islet cell transplantation.
Pathologe. 2011; 32(2):135-143
Doi: 10.1007/s00292-010-1410-2
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Lackner Karoline
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- Abstract:
- The past decade has seen substantial improvements in patient and graft survival after intestinal transplantation. This improvement has been achieved by advances in donor and recipient selection, patient management, immunosuppression and surgical techniques. Intestinal transplantation is therefore considered a therapeutic option in the treatment of short bowel syndrome. Mile stones include the development of the calcineurin inhibitor Tacrolimus for immunosuppression as well as induction therapy using immune modulating substances like interleukin-2 receptor antagonists and antilymphocyte preparations. In addition to improvements in immunosuppression, antimicrobial prophylaxis and diagnosis of rejection, advances in surgical techniques have been crucial to achieving increased graft survival. Pancreas transplantation, generally with simultaneous kidney transplantation, is now available as a treatment option for patients with labile diabetes mellitus (usually type 1). Allogeneic islet transplantation was developed in the 1990s as a minimally invasive alternative to pancreas transplantation. Pancreatic islets are isolated enzymatically from the donor pancreas, in most cases infused into the portal vein and thus engrafted into the liver. Currently, technical and medical problems as well as high costs prevent the application of islet transplantation as a therapeutic option for a larger number of patients with diabetes mellitus.
- Find related publications in this database (using NLM MeSH Indexing)
- Antibiotic Prophylaxis -
- Cooperative Behavior -
- Diabetes Mellitus, Type 1 - pathology
- Graft Rejection - immunology
- Graft Survival - immunology
- Humans -
- Immunosuppressive Agents - therapeutic use
- Interdisciplinary Communication -
- Intestine, Small - immunology
- Islets of Langerhans Transplantation - immunology
- Kidney Transplantation - immunology
- Pancreas - immunology
- Pancreas Transplantation - immunology
- Patient Care Team -
- Postoperative Complications - immunology
- Transplantation Immunology - immunology
- Find related publications in this database (Keywords)
- Transplantation
- Small intestine
- Pancreas
- Islets of Langerhans
- Graft rejection