Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wagner, M; Zollner, G; Trauner, M.
Nuclear receptors in liver disease.
HEPATOLOGY. 2011; 53(3): 1023-1034.
Doi: 10.1002/hep.24148
[OPEN ACCESS]
Web of Science
PubMed
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- Leading authors Med Uni Graz
- Trauner Michael
- Wagner Martin
- Co-authors Med Uni Graz
- Zollner Gernot
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- Abstract:
- Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as well as liver regeneration, inflammation, fibrosis, cell differentiation, and tumor formation. Derangements of nuclear receptor regulation and genetic variants may contribute to the pathogenesis and progression of liver diseases. This places nuclear receptors into the frontline for novel therapeutic approaches for a broad range of hepatic disorders and diseases including cholestatic and fatty liver disease, drug hepatotoxicity, viral hepatitis, liver fibrosis, and cancer.
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