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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Rosenmayr, A; Pointner-Prager, M; Mitterschiffthaler, A; Bozic, L; Pelzmann, B; Tüchler, H; Fae, I; Fischer, GF; Greinix, HT; Peters, Ch; Kalhs, P; Krieger, O; Linkesch, W; Nachbaur, D; Urban, Ch; Posch, U; Lanzer, G; Gabriel, Ch; Schennach, H; Mayr, WR.
What are a patient's current chances of finding a matched unrelated donor? Twenty years' central search experience in a small country.
Bone Marrow Transplant. 2012; 47(2):172-180
Doi: 10.1038/bmt.2011.67
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- Co-authors Med Uni Graz
- GABRIEL Christian
- Greinix Hildegard
- Lanzer Gerhard
- Linkesch Werner
- Posch Ursula
- Urban Ernst-Christian
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- Abstract:
- Between 1988 and 2007, international searches for matched unrelated donors (MUDs) were performed for 1586 Austrian patients. Between 2004 and 2007, a MUD was identified for 76.7% of the patients. Between 1996 and 2003, a donor was identified for 71.3% of the patients, and between 1988 and 1995, only for 53.4% of the patients. Search times of successful searches decreased from 7.7 months in the first period to 1.7 months in the period from 2004 to 2007. However, transplants were not performed in all cases in which a donor was found: only in 61.6% of the patients between 2004 and 2007, in 53.4% between 1996 and 2003 and in 29.6% between 1988 and 1995. Multivariate analysis determined that having a common HLA type was the most important variable impacting on finding a MUD for a patient. Factors that most strongly influence a patient's access to transplant were the patient's European origin and a short time between diagnosis and start of donor search. The strongest factor for both finding a donor and being transplanted was a search being performed during more recent years: patients' chances increased from year to year.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Adult -
- Child -
- Female -
- HLA Antigens - genetics HLA Antigens - immunology
- Hematopoietic Stem Cell Transplantation - methods
- Humans -
- Living Donors - statistics & numerical data Living Donors - supply & distribution
- Male -
- Middle Aged -
- Phenotype -
- Tissue and Organ Procurement - methods
- Unrelated Donors - statistics & numerical data Unrelated Donors - supply & distribution
- Find related publications in this database (Keywords)
- matched unrelated donor
- MUD
- international donor search
- HLA phenotypes