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SHR Neuro Cancer Cardio Lipid Metab Microb

Watzka, SB; Setinek, U; Stubenberger, EB; Totsch, M; Dekan, G; Marcher, M; Fleck, T; Muller, MR.
Integrin-linked kinase, phosphorylated AKT and the prognosis of malignant pleural mesothelioma
EUR J CARDIO-THORAC SURG. 2011; 39(2): 180-184. Doi: 10.1016/j.ejcts.2010.05.007 [OPEN ACCESS]
Web of Science PubMed FullText FullText_MUG

Co-authors Med Uni Graz: Tötsch Martin
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Abstract:: Objective: Integrin-linked kinase (ILK) is a cell membrane-bound molecule implicated in the metastatic progression of many tumour types. It phosphorylates the downstream target AKT (phosphorylated AKT, pAKT), and, by doing this, it activates anti-apoptotic pathways. We have recently shown ILK expression in malignant pleural mesothelioma (MPM). To determine whether ILK expression in MPM is connected with pAKT expression, and whether ILK and pAKT expression have any influence on the patient's prognosis, we correlated ILK and pAKT expression, as assessed by immunohistochemistry, with disease-related survival in a retrospective cohort of 80 MPM patients. Material and methods: The paraffin specimens of 80 MPM cases treated from 1990 to 2006 (52 surgical cases, 28 conservative cases) have been retrieved from the archive. The median (range) patients' age was 62 (28-83 years) years; the male-to-female ratio was 3:1. Fifty percent of the patients had an epitheloid subtype. The samples have been stained with anti-ILK as well as with anti-pAKT and scored by two independent pathologists. Intensity of ILK and pAKTexpression has been correlated with disease-related survival. Results: In total, 73 of 80 (91%) MPM samples expressed ILK; 65 of 74 (88%) MPM samples expressed pAKT. Comparing the 5-year disease-related survival according to ILK or pAKTexpression, no statistically significant difference could be found between ILK and pAKT expressing or non-expressing patients. However, in the subgroup of conservatively treated MPM patients, those with strong ILK expression had a longer 5-year disease-related survival (p < 0.0001). In total, the only prognostic factor across all ILK, pAKT and therapy subgroups was the histological subtype (p = 0.01). The prognostic significance of the histological subtype has been confirmed in multivariate analysis (p = 0.005). Conclusion: The expression of ILK in MPM is connected with the expression of the downstream target pAKT, but neither ILK nor pAKTexpression has a measurable influence on the patient's prognosis, except for certain subgroups of MPM. However, to shed light on the true prognostic impact of ILK and pAKTexpression in MPM, prospective trials are needed. (C) 2010 European Association for Cardio-Thoracic Surgery. Published by Elsevier B.V. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Female -; Humans -; Male -; Mesothelioma - diagnosis; Middle Aged -; Phosphorylation -; Pleural Neoplasms - diagnosis; Prognosis -; Protein-Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Retrospective Studies -; Survival Analysis -; Treatment Outcome -; Tumor Markers, Biological - metabolism
Find related publications in this database (Keywords): Mesothelioma; Integrin-linked kinase; AKT; Survival; Surgery; Chemotherapy; Immunohistochemistry