Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Oettl, K; Reibnegger, G; Schmut, O.
The redox state of human serum albumin in eye diseases with and without complications
ACTA OPHTHALMOL. 2011; 89(2): E174-E179.
Doi: 10.1111/j.1755-3768.2009.01824.x
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- Führende Autor*innen der Med Uni Graz
- Öttl Karl
- Co-Autor*innen der Med Uni Graz
- Reibnegger Gilbert
- Schmut Otto
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- Abstract:
- Purpose: To investigate the redox state of human serum albumin concerning cysteine-34 as a possible systemic redox marker in patients with different eye diseases with and without complications and with consideration of possible effects of age. Methods: Cataract (CAT), glaucoma, age-related macular degeneration (AMD), diabetes mellitus (DM), diabetic retinopathy and hypertension were the pathologies investigated. Albumin redox state concerning cysteine-34 was measured by high-performance liquid chromatography with fluorescence detection. The separation gives three fractions: the fully reduced form containing a thiol group, the disulphide form and a higher oxidized form. Statistical analysis was done by Student's t-test, analysis of variance and stepwise regression analysis. Results: Albumin as a systemic marker for oxidative stress was shifted to a more oxidized state by DM. An even stronger shift to the oxidized form was observed in patients with proliferative diabetic retinopathy. Notably, these effects were independent from age. In contrast, CAT and AMD had no influence on serum albumin redox state. Conclusion: Serum albumin is not shifted to more oxidized forms by localized oxidative stress, but it is in systemic diseases like DM.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Aging - physiology
- Biological Markers - metabolism
- Blood Pressure -
- Chromatography, High Pressure Liquid -
- Cysteine - chemistry
- Diabetes Complications - blood
- Eye Diseases - blood
- Female -
- Humans -
- Hypertension - blood
- Male -
- Middle Aged -
- Oxidation-Reduction -
- Oxidative Stress -
- Serum Albumin - chemistry
- Find related publications in this database (Keywords)
- cataract
- diabetes mellitus
- mercaptalbumin
- oxidative stress
- retinopathy
- thiol groups