Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Ropele, S; Langkammer, C; Enzinger, C; Fuchs, S; Fazekas, F.
Relaxation time mapping in multiple sclerosis.
Expert Rev Neurother. 2011; 11(3): 441-450.
Doi: 10.1586/ern.10.129
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Ropele Stefan
- Co-authors Med Uni Graz
- Enzinger Christian
- Fazekas Franz
- Fuchs Siegrid
- Langkammer Christian
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- Abstract:
- Several relaxation mapping techniques have been proposed to quantitatively assess disease-related brain tissue changes in multiple sclerosis. Newer developments also account for the distribution of hydrogen protons in different tissue compartments, and therefore provide markers for myelin and macromolecular content. This article will cover the broad spectrum of the pulse sequences and analysis techniques related to this topic that are currently available. Various technical and practical limitations linked with specific approaches will be discussed. These include acquisition time, accuracy and precision, radiofrequency absorption and limited coverage of the brain. Finally, the application of these techniques in the context of multiple sclerosis will be reviewed.
- Find related publications in this database (using NLM MeSH Indexing)
- Brain - pathology
- Brain Mapping - methods
- Disease Progression -
- Humans -
- Hydrogen -
- Magnetic Resonance Imaging - methods
- Multiple Sclerosis - physiopathology
- Myelin Sheath - pathology
- Protons -
- Time Factors -
- Find related publications in this database (Keywords)
- follow-up
- iron
- magnetic resonance imaging
- magnetization transfer
- multiple sclerosis
- myelin
- relaxometry
- T-1
- T-2
- T*(2)