Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Pilz, S; Tomaschitz, A; Friedl, C; Amrein, K; Drechsler, C; Ritz, E; Boehm, BO; Grammer, TB; März, W.
Vitamin D status and mortality in chronic kidney disease.
Nephrol Dial Transplant. 2011; 26(11): 3603-3609.
Doi: 10.1093/ndt/gfr076
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- Führende Autor*innen der Med Uni Graz
- Pilz Stefan
- Co-Autor*innen der Med Uni Graz
- Amrein Karin
- Lackner Claudia
- März Winfried
- Tomaschitz Andreas
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- Abstract:
- BACKGROUND: Vitamin D deficiency is found in the majority of patients with chronic kidney disease (CKD) and may contribute to various chronic diseases. Current guidelines suggest correcting reduced 25-hydroxyvitamin D [25(OH)D] concentrations in CKD patients with an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2). Whether low 25(OH)D levels in these patients are associated with higher mortality is unclear. This issue was addressed in the present work. METHODS: We examined 444 patients with eGFR <60 mL/min/1.73 m(2) from the Ludwigshafen Risk and Cardiovascular Health Study. This prospective cohort study includes Caucasian patients without primary kidney disease who were routinely referred to coronary angiography at baseline (1997-2000). RESULTS: During a median follow-up time of 9.4 years, 227 patients died including 159 deaths from cardiovascular causes. Multivariate adjusted hazard ratios (HRs) (with 95% confidence intervals) in severely vitamin D-deficient [25(OH)D <10 ng/mL] compared to vitamin D-sufficient patients [25(OH)D >= 30 ng/mL] were 3.79 (1.71-8.43) for all-cause and 5.61 (1.89-16.6) for cardiovascular mortality. Adjusted HRs per 10 ng/mL increase in 25(OH)D levels were 0.63 (0.50-0.79) for all-cause and 0.59 (0.45-0.79) for cardiovascular mortality. There was no significant interaction with parathyroid hormone concentrations. CONCLUSIONS: Low 25(OH)D levels are associated with increased all-cause and cardiovascular mortality in CKD patients. These findings support suggestions to correct vitamin D deficiency, but whether vitamin D supplementation improves survival remains to be proven in randomized controlled trials.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Cardiovascular Diseases - blood
- Coronary Angiography -
- Female -
- Follow-Up Studies -
- Glomerular Filtration Rate -
- Humans -
- Kidney Failure, Chronic - blood
- Male -
- Prognosis -
- Prospective Studies -
- Risk Factors -
- Survival Rate -
- Vitamin D - analogs and derivatives
- Vitamin D Deficiency - etiology
- Find related publications in this database (Keywords)
- death
- mortality
- prospective
- renal
- vitamin D