Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Le Bouteiller, P; Tabiasco, J; Polgar, B; Kozma, N; Giustiniani, J; Siewiera, J; Berrebi, A; Aguerre-Girr, M; Bensussan, A; Jabrane-Ferrat, N.
CD160: a unique activating NK cell receptor.
Immunol Lett. 2011; 138(2):93-96
Doi: 10.1016/j.imlet.2011.02.003
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Kozma Noemi
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- Abstract:
- Here we discuss CD160 an essential NK cell activating receptor that remains poorly understood. CD160 receptor exhibits a number of unique structural and functional characteristics that are not common to other killer immunoglobulin-like receptors that recognize major histocompatibility complex (MHC) class I molecules: (1) In addition to humans and mice, the cd160 gene is conserved in several other mammal species; (2) cd160 is located outside the NK gene complex and the Leukocyte Receptor Complex in humans; (3) CD160 expression is associated to the CD56(dim) CD16+ cytotoxic NK cell phenotype; (4) both human and mouse CD160 recognize MHC class Ia and Ib molecules; (5) unlike the other MHC class I-dependent activating NK receptors, CD160 is a glycosylphosphatidylinositol-anchored molecule with a single immunoglobulin-like domain, and does not bear immunoreceptor tyrosine-based activation motifs. Consequently, CD160 cannot signal by itself, requiring the recruitment of adaptor proteins. CD160 recruits phosphoinositide-3 kinase to trigger cytotoxicity and cytokine secretion; (6) specific engagement of NK CD160 receptor expressed by circulating NK cells produces proinflammatory cytokines IFN-γ, TNF-α, and, most notably, IL-6 and IL-8 as well as MIP1-β chemokine. The level of CD160-mediated IFN-γ production is always higher than the one observed after engagement of the CD16 receptor.
- Find related publications in this database (using NLM MeSH Indexing)
- 1-Phosphatidylinositol 4-Kinase - genetics
- Adaptor Proteins, Signal Transducing - genetics
- Amino Acid Motifs -
- Animals -
- Antigens, CD - genetics
- Antigens, CD56 - genetics
- Conserved Sequence -
- Cytokines - genetics
- Cytotoxicity, Immunologic -
- GPI-Linked Proteins - genetics
- Gene Expression - immunology
- Genes, MHC Class I - immunology
- Glycosylphosphatidylinositols - genetics
- Humans -
- Killer Cells, Natural - cytology
- Mice -
- Receptors, IgG - genetics
- Receptors, Immunologic - genetics
- Signal Transduction - immunology
- Find related publications in this database (Keywords)
- CD160
- NK cell
- NK cell receptor
- Cell killing
- Cytokines