Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Fritsch, P; Kleber, M; Schlagenhauf, A; Laschnik, B; Fritsch, M; Muntean, W; Mangge, H; Reinehr, T.
Normalization of haemostatic alterations in overweight children with weight loss due to lifestyle intervention.
Atherosclerosis. 2011; 216(1):170-173
Doi: 10.1016/j.atherosclerosis.2011.01.042
Web of Science
PubMed
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FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Fritsch Peter
- Co-Autor*innen der Med Uni Graz
- Fritsch Maria
- Leschnik Bettina
- Mangge Harald
- Muntean Eugen
- Schlagenhauf Axel
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- Abstract:
- Obesity has been shown to be associated with a hypercoagulable state. However, the effect of weight loss on these haemostatic alterations has not been studied yet with an overall function test such as the thrombin generating test (TG) in obese children. We prospectively determined weight status as SDS-BMI, fibrinogen, and performed TG determining time to peak (TTPeak), peak, time preceding the thrombin burst (lag-time), and "endogenous" thrombin potential (ETP) in 27 overweight children (mean age 11.9 ± 2.4 years, 45% female, mean BMI 27.5 ± 5.6 kg/m(2), mean SDS-BMI 2.31 ± 0.48) both at baseline and after 1 year lifestyle intervention based on nutrition education, exercise therapy, and psychological care. Furthermore, thrombin generating test and fibrinogen were determined in 50 healthy children of same age. Overweight children demonstrated significantly higher fibrinogen levels (p = 0.013), shorter lag-time (p < 0.001), and TTPeak (p = 0.028) compared to normal-weight children. ETP (p < 0.001) and peak (p < 0.001) were significantly higher in overweight than in normal-weight children. The overweight children reduced their degree of overweight significantly (-0.4 5 ± 0.22 SDS-BMI; p < 0.001). At the end of the lifestyle intervention, all haemostatic alterations normalized (significant decrease of fibrinogen (p = 0.036), ETP (p = 0.034), and peak (p = 0.001); significant increase of lag-time (p = 0.040) and TTPeak (p < 0.001)). The alterations in the haemostatic system in obese children normalized after weight loss due to lifestyle intervention demonstrating their reversibility. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Behavior Therapy -
- Blood Coagulation Tests -
- Body Mass Index -
- Chi-Square Distribution -
- Child -
- Diet, Reducing -
- Exercise Therapy -
- Female -
- Fibrinogen - metabolism
- Fibrinogen -
- Hemostasis -
- Humans -
- Male -
- Overweight - blood
- Overweight - complications
- Overweight - therapy
- Prospective Studies -
- Risk Reduction Behavior -
- Thrombin - metabolism
- Thrombophilia - blood
- Thrombophilia - etiology
- Thrombophilia - therapy
- Time Factors -
- Treatment Outcome -
- Weight Loss -
- Find related publications in this database (Keywords)
- Thrombin generation test
- Fibrinogen
- Weight loss
- Obesity
- Lifestyle intervention