Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Wutte, N; Berghold, A; Löffler, S; Zenz, W; Daghofer, E; Krainberger, I; Kleinert, G; Aberer, E.
CXCL13 chemokine in pediatric and adult neuroborreliosis.
Acta Neurol Scand. 2011; 124(5):321-328
Doi: 10.1111/j.1600-0404.2010.01477.x
Web of Science
PubMed
FullText
FullText_MUG
- Führende Autor*innen der Med Uni Graz
- Aberer Elisabeth
- Palfner-Wutte Nora Johanna
- Co-Autor*innen der Med Uni Graz
- Berghold Andrea
- Daghofer Elisabeth
- Kleinert Gertrude
- Löffler Sabine
- Zenz Werner
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- Abstract:
- Objectives - Diagnosis of Lyme neuroborreliosis (NB) depends on the proof of intrathecal antibody production against Borrelia burgdorferi. CXCL13 has been seen to be elevated early in NB, before antibody production has started. In this study, we determined the diagnostic role of the CXCL13 chemokine in cerebrospinal fluid (CSF) and serum for the first time in pediatric NB patients as well as in adults, compared to controls and blood donors (BD). Material and Methods - CXCL13 levels were measured in CSF and serum of 33 children and 42 adult patients. Serum CXCL13 was measured in 300 BD. Results - CSF CXCL13 levels were significantly elevated in definite and probable acute NB in children and adults compared to seropositive and seronegative neurological controls (P < 0.001). Serum CXCL13 levels showed great fluctuations and were not significantly elevated in NB patients. Conclusions - Our study suggests that CSF CXCL13 can be used as a diagnostic marker for NB in children as well. In contrast, CXCL13 serum levels show great variance even in the healthy population and are not indicative of active NB.
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Age Factors -
- Chemokine CXCL13 - blood
- Child -
- Child, Preschool -
- Female -
- Humans -
- Infant -
- Infant, Newborn -
- Lyme Neuroborreliosis - blood
- Male -
- Middle Aged -
- Up-Regulation - physiology
- Young Adult -
- Find related publications in this database (Keywords)
- CXCL13 in children
- CXCL13 in serum
- diagnosis
- neuroborreliosis