Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Kopeckı, J; Krusinová, E; Klementová, M; Kazdová, L; Mlejnek, P; Pravenec, M; Hill, M; Pelikánová, T.
Selected adipokines - plasma concentrations and adipose tissue expressions during 24-hour lipid infusion in healthy men.
Physiol Res. 2010; 59(1): 89-96.
Doi: 10.33549/physiolres.931464
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- Co-authors Med Uni Graz
- Svehlikova Eva
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- Abstract:
- Our aim was to assess the reaction of TNFalpha, resistin, leptin and adiponectin to lipid infusion. Eight healthy subjects underwent a 24-hour lasting infusion of lipid emulsion. Plasma concentrations and expressions of selected cytokines in subcutaneous fat were measured. TNFalpha plasma concentration did not change during the first 4 hours of hypertriglyceridemia, but a significant increase after 24 hours was detected (p<0.001 for 0; 30; 240 min vs. 24 h). Plasma concentration of resistin significantly increased at 30 min of infusion and remained elevated (p<0.01 for 0 min vs. 30; 240 min; p<0.001 for 0 min vs. 24 h). Plasma concentrations of leptin and adiponectin did not show any significant changes. Although the expression of resistin in the subcutaneous adipose tissue tended to increase, the change was not significant. Expressions of TNFalpha, leptin and adiponectin were unaffected. In conclusions, our results indicate that acutely induced hyperlipidemia could influence the secretion of TNFalpha and resistin.
- Find related publications in this database (using NLM MeSH Indexing)
- Adipokines - blood
- Adiponectin - blood
- Adult -
- Biological Markers - blood
- Fat Emulsions, Intravenous - administration & dosage
- Fatty Acids, Nonesterified - blood
- Gene Expression Regulation -
- Humans -
- Hyperlipidemias - blood
- Infusions, Intravenous -
- Leptin - blood
- Male -
- Resistin - blood
- Subcutaneous Fat - metabolism
- Time Factors -
- Triglycerides - blood
- Tumor Necrosis Factor-alpha - blood
- Young Adult -
- Find related publications in this database (Keywords)
- Resistin
- TNF alpha
- Leptin
- Adiponectin
- Insulin resistance
- NEFA
- Triglycerides
- Lipotoxicity