Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Perwein, T; Lackner, H; Sovinz, P; Benesch, M; Schmidt, S; Schwinger, W; Urban, C.
Survival and late effects in children with stage 4 neuroblastoma.
Pediatr Blood Cancer. 2011; 57(4): 629-635.
Doi: 10.1002/pbc.23036
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Perwein Thomas
- Co-Autor*innen der Med Uni Graz
- Benesch Martin
- Lackner Herwig
- Ritter-Sovinz Petra
- Schwinger Wolfgang
- Urban Ernst-Christian
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- Abstract:
- Background. Treatment of metastatic neuroblastoma (NB) demands aggressive oncological therapy, which may cause long-term sequelae in survivors. The aim of this retrospective single center study is to give an overview of survival in children with stage 4 NB and to describe the spectrum of late effects seen in survivors. Procedure. Medical records of 31 patients with stage 4 NB treated between 1984 and 2009, who were included in a follow-up programme, were reviewed for information on tumor, treatment and late effects. Results. Five-year overall survival was 54.3 +/- 9% and 5-year event-free survival was 44.9 +/- 9%. Patients diagnosed after 1996 had a significantly better survival rate than those diagnosed before (74 +/- 11.2% vs. 33.3 +/- 12.2%, P = 0.011). In 15 of the 16 survivors (93.8%), numerous late effects were detected. The most common long-term sequelae were renal changes in 10 patients (62.5%) and endocrine disturbances in 9 patients (56.3%), including hypothyroidism with need of substitution in 50%, GH deficiency in 37.5% and hypogonadism in 12.5%. Sensorineural hearing loss occurred in 37.5% of survivors. Further observed late effects were hepatobiliary changes (31.3%), musculoskeletal problems, and pulmonary abnormalities (each 25%), as well as neurologic changes (18.8%), dental defects (12.5%), and unilateral blindness (6.3%). Second neoplasms appeared in 3 patients, 1 of whom died of hepatocellular carcinoma following infection with hepatitis B. Conclusions. More than 50% of children with stage 4 NB may survive. The high incidence of severe long-term sequelae underlines the importance of careful follow-up in order to detect and treat late effects early enough. Pediatr Blood Cancer 201157:629-635. (C) 2011 Wiley-Liss, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - therapeutic use
- Child -
- Child, Preschool -
- Disease-Free Survival -
- Female -
- Humans -
- Incidence -
- Infant -
- Kaplan-Meier Estimate -
- Male -
- Neoplasm Staging -
- Neoplasms, Second Primary - epidemiology
- Neuroblastoma - complications
- Radiotherapy - adverse effects
- Retrospective Studies -
- Survivors -
- Find related publications in this database (Keywords)
- children
- late effects
- neuroblastoma
- survival