Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Vucur, M; Roderburg, C; Bettermann, K; Tacke, F; Heikenwalder, M; Trautwein, C; Luedde, T.
Mouse models of hepatocarcinogenesis: what can we learn for the prevention of human hepatocellular carcinoma?
Oncotarget. 2010; 1(5):373-378
Doi: 10.18632/oncotarget.170
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- Co-Autor*innen der Med Uni Graz
- Bettermann Kira
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- Abstract:
- There is growing evidence that chronic inflammatory processes are involved in triggering the sequence from chronic liver injury to liver fibrosis, ultimately leading to liver cancer. In the last years this process has been recapitulated in a growing number of different mouse models. However, it has remained unclear whether and how these mouse models reflect the clinical reality of human hepatocellular carcinoma (HCC). Research with animal models but also human liver specimens has indicated that the NF-κB signaling pathway might withhold a crucial function in the mediation of chronic hepatic inflammation and the transition to HCC in humans. However, previous studies led to divergent and partly conflicting results with regards to the functional role of NF-κB in hepatocarcinogenesis. Here, we discuss a new genetic mouse model for HCC, the liver-specific TAK1 knockout mouse, which lacks the NF-κB activating kinase TAK1 specifically in parenchymal liver cells. Molecular findings in this mouse model and their possible significance for chemopreventive strategies against HCC are compared to other murine HCC models.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Anti-Inflammatory Agents - therapeutic use
- Carcinoma, Hepatocellular - enzymology
- Cell Transformation, Neoplastic - drug effects
- Disease Models, Animal -
- Hepatitis - drug therapy
- Humans -
- Inflammation Mediators - metabolism
- Liver - drug effects
- Liver Neoplasms - enzymology
- MAP Kinase Kinase Kinases - deficiency
- Mice -
- Mice, Knockout -
- NF-kappa B - metabolism
- Signal Transduction - drug effects
- Find related publications in this database (Keywords)
- HCC
- mouse models
- TAK1
- DEN
- inflammation
- signaling