Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Aigner, RM; Fueger, GF; Vejda, M.
Follow-up of osteomyelitis of infants with systemic serum parameters and bone scintigraphy.
Nuklearmedizin. 1996; 35(4):116-121
Doi: 10.1055/s-0038-1629824
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- Führende Autor*innen der Med Uni Graz
- Aigner Reingard
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- Abstract:
- Aim: To prevent orthopedic sequelae in acute hematogenous pyogenic osteomyelitis (AHPO) of infants early diagnosis, recognition of recurrence and effective therapy is needed. This retrospective study of 47 infants with bacteriologically confirmed AHPO concerned with an analysis of the diagnostic value of systemic serum parameters compared to bone scintigraphy (BSC). Methods: AHPO was characterized initially and during the course of disease by clinical findings, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), total and differential white blood cell (WBC) count, BSC, and plain radiography. Results: CRP was the most effective serum parameter for follow-up of disease. The first sign of BSC to signal adequate response to antibiotic treatment was the decrease or normalization of hyperperfusion. Escape from therapy or poor prognosis, even when the serum parameters were normalized, was signaled by the recurrence of focal hyperperfusion and the persistent or increasing local uptake ratios on the 3-h-image over 6 weeks during a course of antibiotic treatment. Conclusion: Antibiotic treatment masks the clinical presentation, and the radiographic findings, causes non-characteristic laboratory findings, but do not prevent the scintigraphic visualization; BSC and serum parameters used in the right completion are the most successful and efficient modalities for followup of AHPO. Maintenance of antibiotic therapy should be done until BSC findings have reverted to normal.
- Find related publications in this database (using NLM MeSH Indexing)
- Anti-Bacterial Agents - therapeutic use
- Bacterial Infections - epidemiology
- Biological Markers - blood
- Blood Sedimentation -
- Bone and Bones - radiography Bone and Bones - radionuclide imaging
- C-Reactive Protein - analysis
- Female -
- Follow-Up Studies -
- Humans -
- Infant -
- Leukocyte Count -
- Male -
- Osteomyelitis - blood Osteomyelitis - drug therapy Osteomyelitis - radionuclide imaging
- Recurrence -
- Retrospective Studies -
- Time Factors -
- Find related publications in this database (Keywords)
- Acute Hematogenous Osteomyelitis
- Septic Arthritis
- Bone Scintigraphy
- Infants