Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
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Geroldinger-Simic, M; Zelniker, T; Aberer, W; Ebner, C; Egger, C; Greiderer, A; Prem Md, N; Lidholm, J; Ballmer-Weber, BK; Vieths, S; Bohle, B.
Birch pollen-related food allergy: Clinical aspects and the role of allergen-specific IgE and IgG(4) antibodies.
J Allergy Clin Immunol. 2011; 127(3): 616-622.
Doi: 10.1016/j.jaci.2010.10.027
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- Co-Autor*innen der Med Uni Graz
- Aberer Werner
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- Abstract:
- Background: Patients with birch pollen allergy often develop allergic reactions to plant foods. Objective: To evaluate the prevalence, main symptoms, and triggers of birch pollen-related food allergy and the role of food-specific IgG(4) antibodies in food tolerance. Methods: Food-induced symptoms were evaluated in 225 individuals with birch pollen allergy by using a standardized questionnaire. IgE and IgG(4) levels specific for the major birch pollen allergen Bet v 1 and birch profilin Bet v 2 and the Bet v 1 homologs in apple (Mal d 1) and hazelnut (Cor a 1) were quantified by ImmunoCAP. Mock-treated and IgG-depleted sera from patients tolerating hazelnuts in food challenges were compared for their inhibitory activity for binding of Cor a 1-IgE complexes to B cells. Results: In total, 73% of the study population experienced food allergy, which was perennial in 86% of the affected individuals. The oral allergy syndrome was the main clinical manifestation. However, more than 58% of the patients also experienced food-induced rhinoconjunctivitis. Apples and hazelnuts were identified as the most frequent triggers. Food allergy correlated with IgE reactivity to Bet v 1 but not to Bet v 2. Mal d 1-specific and Cor a 1-specific IgG(4)/IgE ratios were significantly higher in food-tolerant individuals than individuals with food allergy. Sera from IgG(4)-positive food-tolerant patients possessed IgG-dependent IgE-inhibitory activity. Conclusion: Birch pollen-related food allergy is highly prevalent and often perennial. High food allergen-specific IgG(4)/IgE ratios seem associated with food tolerance, potentially because specific IgG(4) blocks IgE binding to food allergens. Thus, the presence of food allergen-specific IgG(4) antibodies is no diagnostic marker for birch pollen-related food allergy. (J Allergy Clin Immunol 2011;127:616-22.)
- Find related publications in this database (using NLM MeSH Indexing)
- Adolescent -
- Adult -
- Aged -
- Antigens, Plant - classification
- Betula - immunology
- Child -
- Female -
- Food Hypersensitivity - immunology
- Humans -
- Immunoglobulin E - blood
- Immunoglobulin G - blood
- Male -
- Middle Aged -
- Pollen - immunology
- Questionnaires -
- Find related publications in this database (Keywords)
- Birch pollen allergy
- food allergy
- oral allergy syndrome
- Bet v 1
- IgE
- blocking antibodies