Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Müller-Berghaus, J; Ehlert, K; Ugurel, S; Umansky, V; Bucur, M; Schirrmacher, V; Beckhove, P; Schadendorf, D.
Melanoma-reactive T cells in the bone marrow of melanoma patients: association with disease stage and disease duration.
Cancer Res. 2006; 66(12):5997-6001
Doi: 10.1158/0008-5472.CAN-04-0484
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- Co-Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- Using IFN-gamma enzyme-linked immunospot, we investigated reactivity of T cells from bone marrow and peripheral blood to melanoma lysate-pulsed autologous dendritic cells in 40 melanoma patients. Melanoma-reactive T cells were present in the bone marrow of seven patients and in peripheral blood of four patients. In the bone marrow, melanoma-reactive T cells were present in 6 of 21 stage IV patients and in 1 of 10 stage III patients, whereas none were detected in stage I to II patients (0 of 9). The occurrence of tumor-reactive bone marrow T cells in melanoma patients was associated with advanced disease stage, disease duration and tumor load, and independent of treatment. These findings provide new insights into the generation of T-cell responses in melanoma patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Bone Marrow Cells - immunology Bone Marrow Cells - pathology
- Dendritic Cells - immunology
- Female -
- Humans -
- Immunotherapy, Adoptive - methods
- Interferon-gamma - biosynthesis Interferon-gamma - immunology
- Male -
- Melanoma - immunology Melanoma - pathology Melanoma - therapy
- Middle Aged -
- Neoplasm Staging -
- T-Lymphocytes - immunology T-Lymphocytes - pathology