Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
SHR Neuro Krebs Kardio Lipid Stoffw Microb
Ugurel, S.
Serum markers for melanoma.
Hautarzt. 2005; 56(2):173-184
Doi: 10.1007/s00105-004-0893-2
Web of Science
PubMed
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- Führende Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- Tumor markers in the serum of cancer patients have an important role in clinical diagnosis and in prognosis, and also in the monitoring of the patients' disease and response to therapy over time. The serum markers currently available for melanoma have only limited clinical use. Those most widely used in clinical applications are S100-beta, melanoma inhibitory activity, and lactate dehydrogenase; there are close correlations between the serum concentrations of these and tumor load. Regular determination of S100-beta and MIA levels during follow-up can therefore be used for early detection of a tumor relapse in melanoma patients, increased serum concentrations of these marker proteins being indicative of tumor growth. Patients with distant metastases from melanoma who present with elevated serum levels of S100-beta, MIA, or LDH have poorer overall survival than do patients whose serum concentrations are within normal ranges. These three markers can also be used to monitor the course of disease and therapy outcome in patients with distant metastases. Since there are no marker proteins for melanoma that are not dependent on tumor load, it is not currently possible to forecast the survival of patients who are tumor free after surgery. Serum markers are also not suitable for screening or for the diagnosis of primary melanomas.
- Find related publications in this database (using NLM MeSH Indexing)
- Disease Progression -
- Extracellular Matrix Proteins -
- Follow-Up Studies -
- Humans -
- L-Lactate Dehydrogenase - blood
- Lymph Nodes - pathology
- Melanoma - blood Melanoma - diagnosis Melanoma - mortality
- Neoplasm Proteins -
- Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - mortality
- Nerve Growth Factors -
- Predictive Value of Tests -
- Prognosis -
- Proteins - metabolism
- Reference Values -
- S100 Proteins - blood
- Sentinel Lymph Node Biopsy -
- Skin Neoplasms - blood Skin Neoplasms - diagnosis Skin Neoplasms - mortality
- Survival Analysis -
- Tumor Markers, Biological - blood
- Find related publications in this database (Keywords)
- malignant melanoma
- serum markers
- disease monitoring
- prognosis
- follow-up