Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
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SHR Neuro Krebs Kardio Lipid Stoffw Microb
Utikal, J; Schadendorf, D; Ugurel, S.
Serologic and immunohistochemical prognostic biomarkers of cutaneous malignancies.
Arch Dermatol Res. 2007; 298(10):469-477
Doi: 10.1007/s00403-006-0726-5
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- Co-Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- Biomarkers are important tools in clinical diagnosis and prognostic classification of various cutaneous malignancies. Besides clinical and histopathological aspects (e.g. anatomic site and type of the primary tumour, tumour size and invasion depth, ulceration, vascular invasion), an increasing variety of molecular markers have been identified, providing the possibility of a more detailed diagnostic and prognostic subgrouping of tumour entities, up to even changing existing classification systems. Recently published gene expression or proteomic profiling data relate to new marker molecules involved in skin cancer pathogenesis, which may, after validation by suitable studies, represent future prognostic or predictive biomarkers in cutaneous malignancies. We, here, give an overview on currently known serologic and newer immunohistochemical biomarker molecules in the most common cutaneous malignancies, malignant melanoma, squamous cell carcinoma and cutaneous lymphoma, particularly emphasizing their prognostic and predictive significance.
- Find related publications in this database (using NLM MeSH Indexing)
- Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology
- Humans -
- Lymphoma, T-Cell, Cutaneous - blood Lymphoma, T-Cell, Cutaneous - diagnosis Lymphoma, T-Cell, Cutaneous - pathology
- Melanoma - blood Melanoma - diagnosis
- Predictive Value of Tests -
- Prognosis -
- Skin Neoplasms - blood Skin Neoplasms - diagnosis Skin Neoplasms - pathology
- Tumor Markers, Biological - blood
- Find related publications in this database (Keywords)
- skin cancer
- biomarker
- prognosis
- serum
- immunohistochemistry