Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Gross, T; Wagner, A; Ugurel, S; Tilgen, W; Reinhold, U.
Identification of TIA-1+ and granzyme B+ cytotoxic T cells in lichen sclerosus et atrophicus.
Dermatology. 2001; 202(3):198-202
Doi: 10.1159/000051636
Web of Science
PubMed
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- Co-Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- Background: The onset and persistence of cutaneous lichen sclerosus et atrophicus (LSA) are linked to the presence of an inflammatory infiltrate of CD3+ T cells that includes CD4+ and CD8+ cells. The functional relevance of the presence of these cells is unknown. Objective: The study intended to quantify resting and activated cytotoxic T cells in LSA lesions. Methods: Twenty patients with active LSA were studied. Skin-infiltrating T cells were immunohistologically characterized with antibodies against CD3, CD8, T-cell-restricted intracellular antigen (TIA-1) and granzyme B (GrB). TIA-1 labels cytotoxic granules of resting and activated T cells, whereas GrB designates activated cytotoxic T lymphocytes (CTL). Results: In all cases, numerous T cells were consistently found expressing cytotoxic granules. The results indicated a high number of infiltrating CD8+ TIA+ T cells. Furthermore, a notable number of GrB+ activated CTL associated with hydropic degeneration of the basal cell layer were found within the dermal infiltrate and at the dermoepidermal interface. Conclusion: This study shows that a high proportion of skin-infiltrating T cells in LSA has a potential cytotoxic function. The results indicate that hydropic degeneration of basal keratinocytes may at least partially be mediated by CTL-dependent mechanisms. Our data also indicate that a cell-mediated immune response may play an important role in the pathogenesis of the disease. Copyright (C) 2001 S. Karger AG, Basel.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Antigens, CD3 - analysis
- Antigens, CD8 - analysis
- Female -
- Granzymes -
- Humans -
- Immunohistochemistry -
- Immunophenotyping -
- Lichen Sclerosus et Atrophicus - immunology Lichen Sclerosus et Atrophicus - metabolism Lichen Sclerosus et Atrophicus - pathology
- Male -
- Membrane Proteins - analysis
- Middle Aged -
- Poly(A)-Binding Proteins -
- Proteins -
- RNA-Binding Proteins - analysis
- Serine Endopeptidases - analysis
- T-Lymphocytes, Cytotoxic - chemistry T-Lymphocytes, Cytotoxic - pathology
- Find related publications in this database (Keywords)
- lichen sclerosus
- cytotoxic T lymphocytes
- cytolytic proteins