Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Reinhold, U; Seiter, S; Ugurel, S; Tilgen, W.
Treatment of progressive pigmented purpura with oral bioflavonoids and ascorbic acid: an open pilot study in 3 patients.
J Am Acad Dermatol. 1999; 41(2 Pt 1):207-208
Doi: 10.1016/S0190-9622(99)70050-2
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- Co-Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- Background: Bioflavonoids and ascorbic acid have been shown to increase capillary resistance and to mediate potent antioxidative radical scavenging activities. Objective: We evaluated the clinical effect of oral bioflavonoids and ascorbic acid in patients with chronic progressive pigmented purpura (PPP). Methods: In an open pilot study, oral rutoside (50 mg twice a day) and ascorbic acid (500 mg twice a day) were administered to 3 patients with chronic PPP. Results: At the end of the 4-week treatment period, complete clearance of the skin lesions was achieved in all 3 patients. No adverse reactions were noted. All patients remained free of lesions at the end of 3 months after treatment. Conclusion: Our results suggest a beneficial effect of bioflavonoids in combination with ascorbic acid on PPP! Because the disease is mostly resistant to other treatment modalities, placebo-controlled studies are necessary to determine the usefulness of this therapy in PPP.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Adult -
- Aged -
- Antioxidants - administration and dosage Antioxidants - therapeutic use
- Ascorbic Acid - administration and dosage Ascorbic Acid - therapeutic use
- Child -
- Female -
- Flavonoids - administration and dosage Flavonoids - therapeutic use
- Humans -
- Pigmentation Disorders - drug therapy
- Pilot Projects -
- Purpura - drug therapy
- Rutin - administration and dosage Rutin - analogs and derivatives Rutin - therapeutic use