Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Rappl, G; Abken, H; Muche, JM; Sterry, W; Tilgen, W; André, S; Kaltner, H; Ugurel, S; Gabius, HJ; Reinhold, U.
CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death.
Leukemia. 2002; 16(5):840-845
Doi: 10.1038/sj.leu.2402438
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- Co-Autor*innen der Med Uni Graz
- Ugurel-Becker Selma
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- Abstract:
- In early stages of cutaneous T cell lymphoma (Sézary syndrome) both CD4+CD7- and CD4+CD7+ T cells clonally expand whereas in late stages of the disease CD7- cells are predominant in number, giving rise to the question whether CD7- T cells have a survival advantage in the skin. Galectin-1, a cell-bound lectin, was recently reported to trigger apoptosis in activated CD7+ T cells. Here, we demonstrate that in contrast to activated CD7(+) T cells, quiescent and activated CD69+ CD7- T cells from healthy donors and from Sézary patients are resistant to galectin-1-mediated cell death. CD7- T cells are apoptosis-resistant even during coculture with IFN-gamma-stimulated endothelial cells that constitutively express galectin-1 in high amounts. These data imply that resistance of CD7- T cells to galectin-1-induced apoptosis may contribute to the accumulation of CD7- Sézary T cells during progression of the disease.
- Find related publications in this database (using NLM MeSH Indexing)
- Adjuvants, Immunologic - pharmacology
- Adolescent -
- Adult -
- Aged -
- Antigens, CD4 - analysis
- Antigens, CD7 - analysis Antigens, CD7 - drug effects
- Apoptosis - drug effects
- CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology
- Case-Control Studies -
- Child -
- Drug Resistance, Neoplasm -
- Female -
- Galectin 1 -
- Hemagglutinins - pharmacology
- Humans -
- Lymphocyte Activation -
- Male -
- Middle Aged -
- Sezary Syndrome - drug therapy Sezary Syndrome - immunology Sezary Syndrome - pathology
- Find related publications in this database (Keywords)
- apoptosis
- CD7
- cutaneous T cell lymphoma
- galectin-1